Phosphorylation of αS1-casein is regulated by different genes

Journal of Dairy Science
E BijlH Bovenhuis

Abstract

Casein phosphorylation is a posttranslational modification catalyzed by kinase enzymes that attach phosphate groups to specific AA in the protein sequence. This modification is one of the key factors responsible for the stabilization of calcium phosphate nanoclusters in casein micelles and for the internal structure of the casein micelles. α(S1)-Casein (α(s1)-CN) is of special interest because it constitutes up to 40% of the total casein fraction in milk, and it has 2 common phosphorylation states, with 8 (α(S1)-CN-8P) and 9 (α(S1)-CN-9P) phosphorylated serine residues. Factors affecting this variation in the degree of phosphorylation are not currently known. The objective of this research was to determine the genetic background of α(S1)-CN-8P and α(S1)-CN-9P. The genetic and phenotypic correlation between α(S1)-CN-8P and α(S1)-CN-9P was low (0.18 and 0.19, respectively). This low genetic correlation suggests a different genetic background. These differences were further investigated by means of a genome-wide association study, which showed that both α(S1)-CN-8P and α(S1)-CN-9P were affected by a region on Bos taurus autosome (BTA) 6, but only α(S1)-CN-8P was affected by a region on BTA11 that contains the gene that encodes for...Continue Reading

References

Aug 1, 1977·Journal of Dairy Science·E W Bingham, H M Farrell
Sep 1, 1977·European Journal of Biochemistry·W MansonW D Annan
Dec 11, 1990·Nucleic Acids Research·D W Threadgill, J E Womack
May 4, 2002·Nature Cell Biology·Philip Cohen
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Sep 30, 2004·Journal of Dairy Science·H M FarrellH E Swaisgood
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Margaret C Neville
Jun 23, 2007·Nature Reviews. Molecular Cell Biology·Jeffrey A Ubersax, James E Ferrell
Sep 27, 2007·Animal Genetics·A SchenninkJ A M van Arendonk
Feb 24, 2009·Journal of Dairy Science·G C B SchopenJ A M van Arendonk
Feb 24, 2009·Journal of Dairy Science·J M L HeckA C M van Hooijdonk
Apr 28, 2009·BMC Genomics·Yue LiuRichard A Gibbs
May 17, 2011·BMC Genetics·Aniek C BouwmanJohan A M van Arendonk
May 25, 2011·Journal of Dairy Science·G C B SchopenH Bovenhuis
Apr 25, 2012·Journal of Evolutionary Biology·C Holt, J A Carver

❮ Previous
Next ❯

Citations

Dec 29, 2015·Journal of Dairy Science·Jakub CieslakMariusz Mackowski
Aug 9, 2017·Molecular Nutrition & Food Research·Simone KönigJoachim Jose
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Panagiota KolitsidaHagai Abeliovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.