PMID: 8584225Oct 13, 1995Paper

Phosphorylation of tau in apolipoprotein E-deficient mice

Neuroscience Letters
I GenisD M Michaelson

Abstract

It has been suggested that the deleterious effects of the allele E4 of apolipoprotein E (apoE) in Alzheimer's disease (AD) are related to its inability to interact with the microtubule associated protein tau and to thereby prevent its hyperphosphorylation. In the present study we investigated the effects of apoE on tau phosphorylation by immunoblot analysis of the levels and extents of phosphorylation of tau of apoE-deficient mice. This revealed that mAb AT8, which is directed against a phosphorylated tau epitope, labels tau of the apoE-deficient mice more intensely than that of control mice and that the opposite occurs with mAb Tau1, which is directed against dephosphorylated tau epitopes. mAb ALZ50 also labeled the tau enriched preparations of the apoE-deficient mice more intensely than those of the controls, whereas the extents of their labeling by the phosphorylation insensitive anti-tau mAb 134 were similar. These results suggest that tau of apoE-deficient mice is hyperphosphorylated.

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Citations

Oct 26, 1999·Journal of Neuroscience Research·L LomnitskiD M Michaelson
May 8, 2000·Journal of Neuroscience Research·L GenisD M Michaelson
Feb 19, 2000·Biochemical and Biophysical Research Communications·V N Trieu, F M Uckun
Oct 13, 1995·Neuroscience Letters·I GordonD M Michaelson
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·L LomnitskiD M Michaelson
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·G A HigginsJ C Barnes
Aug 1, 1997·Trends in Biotechnology·F TheuringJ D Turner
Dec 1, 1996·Progress in Neurobiology·E MasliahW Samuel
Aug 11, 1998·Neuroscience Letters·M L Caillet-BoudinA Delacourte
Mar 4, 1998·Neuroscience·T A RobertsonJ M Papadimitriou
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O KleifeldD M Michaelson
Apr 2, 1999·Biochimica Et Biophysica Acta·L LomnitskiD M Michaelson
Dec 15, 2006·Molecular Neurodegeneration·Hyang-Sook HoeG William Rebeck
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·X BiG Lynch
Nov 18, 2005·FEBS Letters·Atiqur RahmanAngel Cedazo-Mínguez
Mar 20, 2003·Journal of Neuroscience Research·Javier Sáez-ValeroJuan M Luque
Aug 31, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·L LomnitskiD M Michaelson
Mar 18, 2011·Journal of Neuropathology and Experimental Neurology·Frauke GlöcknerThomas G Ohm
Mar 9, 2007·Trends in Molecular Medicine·Robert AdalbertMichael P Coleman
Mar 17, 2001·Nature Reviews. Neuroscience·J Herz, U Beffert
Mar 23, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jin Young LeeChen-Yu Liao
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nobutaka OhkuboNoriaki Mitsuda
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Angela KuhlaBrigitte Vollmar
May 21, 1999·Journal of Neuroscience Research·D FlahertyJ G Wood
Sep 19, 2018·Neurochemical Research·Sonia Sanz MuñozLezanne Ooi
Mar 21, 2019·BMC Medicine·Mirna SafiehDaniel M Michaelson
Sep 27, 2000·Journal of Neuropathology and Experimental Neurology·A M Saunders
Oct 9, 2020·EJNMMI Research·Angela KuhlaBrigitte Vollmar

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