Phosphorylation of the carboxyl-terminal region of dystrophin

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
M MichalakJ E Hance

Abstract

Dystrophin is a protein product of the gene responsible for Duchenne and Becker muscular dystrophy. The protein is localized to the inner surface of sarcolemma and is associated with a group of membrane (glyco)proteins. Dystrophin links cytoskeletal actins via the dystrophin-associated protein complex to extracellular matrix protein, laminin. This structural organization implicates the role of dystrophin in stabilizing the sarcolemma of muscle fibers. Precisely how dystrophin functions is far from clear. The presence of an array of isoforms of the C-terminal region of dystrophin suggests that dystrophin may have functions other than structural. In agreement, many potential phosphorylation sites are found in the C-terminal region of dystrophin, and the C-terminal region of dystrophin is phosphorylated both in vitro and in vivo by many protein kinases, including MAP kinase, p34cdc2 kinase, CaM kinase, and casein kinase, and is dephosphorylated by calcineurin. The C-terminal domain of dystrophin is also a substrate for hierarchical phosphorylation by casein kinase-2 and GSK-3. These observations, in accordance with the finding that the cysteine-rich region binds to Ca2+, Zn2+, and calmodulin, suggest an active involvement of dystr...Continue Reading

References

Jun 1, 1992·Trends in Biochemical Sciences·S L Pelech, J S Sanghera
Aug 1, 1992·Trends in Biochemical Sciences·M S Anderson, L M Kunkel
Jun 15, 1992·Biochemical and Biophysical Research Communications·R MadhavanH W Jarrett
Sep 20, 1991·Cell·J M Ervasti, K P Campbell
Feb 16, 1995·Nature·T Pawson
May 1, 1995·Human Molecular Genetics·V N D'SouzaP N Ray
Aug 22, 1995·Biochemistry·J ZondloE Eisenstein
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S LuanS L Schreiber
Dec 1, 1994·Journal of Muscle Research and Cell Motility·E FabbrizioD Mornet
Mar 1, 1995·Human Molecular Genetics·H G LidovL M Kunkel
Jan 5, 1995·Biochemical and Biophysical Research Communications·L SenterG Salviati
Mar 10, 1995·The Journal of Biological Chemistry·H W Jarrett, J L Foster
Nov 21, 1994·FEBS Letters·A Bonet-KerracheD Mornet
Apr 1, 1993·Nature Genetics·A H Ahn, L M Kunkel
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M TinsleyK E Davies
May 17, 1994·Biochemistry·R Madhavan, H W Jarrett
Aug 1, 1993·The Journal of Cell Biology·J M Ervasti, K P Campbell
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh
Jul 1, 1993·The Biochemical Journal·M LuiseG Salviati
May 1, 1993·Nature Genetics·T J ByersL M Kunkel
Nov 27, 1995·FEBS Letters·S BakshM Michalak
Jan 1, 1996·Trends in Biochemical Sciences·C P PontingS J Winder

❮ Previous
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Citations

Apr 7, 2000·Brain Research. Brain Research Reviews·M F Mehler
Aug 23, 2003·Molecular and Cellular Neurosciences·Raghavan MadhavanH Benjamin Peng
Feb 7, 2008·The Journal of Biological Chemistry·Joseph G ReynoldsFrancisco J Naya
Jun 2, 2011·International Journal of Alzheimer's Disease·Calum Sutherland
Aug 5, 2008·Neurochemical Research·Joel Cerna CortésBulmaro Cisneros
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Caroline Perronnet, Cyrille Vaillend
Nov 7, 2001·Current Biology : CB·M C Mariol, L Ségalat
Jun 7, 2015·Annual Review of Genomics and Human Genetics·Simon GuiraudLouis M Kunkel
Mar 7, 2003·Human Molecular Genetics·Satoru NoguchiIchizo Nishino
Feb 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Tomohiko SumidaHiroji Imamura
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·Basil J Petrof
Oct 22, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuji Miura
Oct 4, 2000·Physiological Reviews·F Rusnak, P Mertz
Oct 19, 1999·Biochimica Et Biophysica Acta·R Madhavan, H W Jarrett
Mar 18, 2021·American Journal of Physiology. Cell Physiology·Kristy SwiderskiGordon S Lynch

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