PMID: 6171823Nov 1, 1981Paper

Phosphorylation of the same specific protein during amylase release evoked by beta-adrenergic or cholinergic agonists in rat and mouse parotid glands

Proceedings of the National Academy of Sciences of the United States of America
R Jahn, H D Söling

Abstract

Stimulation of amylase secretion from the rat parotid gland by beta-adrenergic agonists is associated with a specific phosphorylation of three membrane-bound proteins designated as proteins I, II, and III [Jahn, R., Unger, C. & Söling, H. D. (1980) Eur. J. Biochem. 112, 345-352]. In contrast, stimuliation by carbachol induced significant phosphorylation of only protein I. This phosphorylation was low compared to isoproterenol-induced phosphorylation but corresponded to the smaller enhancement of amylase secretion. The mouse organ, however, is almost equally sensitive to beta-adrenergic and to cholinergic agonists. Incubation of mouse parotid gland slices with either 20 microM isoproterenol or 10 microM carbachol resulted in strong and comparable releases of amylase, which were accompanied by comparable phosphorylations of protein I. Proteins II and III were phosphorylated only in the presence of isoproterenol. Removal of external calcium by ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetate abolished the carbachol-induced release of amylase but not the phosphorylation of protein I. Isoproterenol-induced secretion of amylase and phosphorylation of proteins I, II, and III were not inhibited under these conditions. ...Continue Reading

Citations

Feb 15, 1988·Biochemical and Biophysical Research Communications·H ShimomuraT R Soderling
Sep 1, 1994·The International Journal of Biochemistry·M Hara-YokoyamaS Furuyama
Jan 1, 1985·Advances in Enzyme Regulation·H D SölingW Fest
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D O QuissellK A Barzen
Oct 1, 1984·The Journal of Cell Biology·T N SpearmanF R Butcher
Sep 1, 1987·European Journal of Biochemistry·G Mieskes, H D Söling
Sep 20, 1993·Annals of the New York Academy of Sciences·B J Baum
Oct 15, 1984·Experientia·D E HarrisonJ M Lord
Oct 20, 1982·Biochimica Et Biophysica Acta·O H Petersen
Aug 1, 1985·Clinical Endocrinology·B L BrownS Tomlinson
Feb 1, 1984·Journal of Dental Research·M I Mednieks, A R Hand
Feb 1, 1983·Journal of Dental Research·D O QuissellK A Barzen
Apr 7, 1986·FEBS Letters·T Takuma, T Ichida
Jan 1, 1984·Journal of Receptor Research·T J Resink, F R Bühler
Apr 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keitaro SatohHiroshi Sugiya
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D O QuissellF J Dowd
Feb 1, 1987·Journal of Dental Research·B J Baum
Jan 1, 1988·The American Journal of Physiology·J J Morrissey

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