Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity

The Plant Cell
Bo LiLibo Shan

Abstract

Proper control of immune-related gene expression is crucial for the host to launch an effective defense response. Perception of microbe-associated molecular patterns (MAMPs) induces rapid and profound transcriptional reprogramming via unclear mechanisms. Here, we show that ASR3 (ARABIDOPSIS SH4-RELATED3) functions as a transcriptional repressor and plays a negative role in regulating pattern-triggered immunity (PTI) in Arabidopsis thaliana. ASR3 belongs to a plant-specific trihelix transcription factor family for which functional studies are lacking. MAMP treatments induce rapid phosphorylation of ASR3 at threonine 189 via MPK4, a mitogen-activated protein kinase that negatively regulates PTI responses downstream of multiple MAMP receptors. ASR3 possesses transcriptional repressor activity via its ERF-associated amphiphilic repression motifs and negatively regulates a large subset of flg22-induced genes. Phosphorylation of ASR3 by MPK4 enhances its DNA binding activity to suppress gene expression. Importantly, the asr3 mutant shows enhanced disease resistance to virulent bacterial pathogen infection, whereas transgenic plants overexpressing the wild-type or phospho-mimetic form of ASR3 exhibit compromised PTI responses. Our stu...Continue Reading

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Citations

Dec 10, 2015·Journal of Experimental Botany·Tong ZhangAlice C Harmon
May 14, 2016·Seminars in Cell & Developmental Biology·Christopher M GarnerWalter Gassmann
May 14, 2016·Cell Host & Microbe·Bo LiPing He
Jul 5, 2016·Frontiers in Plant Science·Guido DurianSaijaliisa Kangasjärvi
Aug 2, 2016·Nature Reviews. Immunology·Daniel Couto, Cyril Zipfel
Nov 15, 2017·Molecular Plant-microbe Interactions : MPMI·Yujun PengYuelin Zhang
Apr 9, 2020·The Plant Journal : for Cell and Molecular Biology·Yukino NittaYuelin Zhang
May 20, 2017·Annual Review of Phytopathology·Xiao YuLibo Shan
Jun 12, 2019·International Journal of Molecular Sciences·Junjie YinJing Wang
Oct 6, 2020·The Plant Genome·Alexander Q WixomAllan B Caplan
May 24, 2018·Cellular and Molecular Life Sciences : CMLS·Karen Thulasi DevendrakumarYuelin Zhang
Apr 27, 2018·Frontiers in Plant Science·Jean Bigeard, Heribert Hirt
Apr 14, 2018·International Journal of Molecular Sciences·Xiaoli LiuYonggen Lou
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ning WangJian Ye
Dec 22, 2017·The Plant Journal : for Cell and Molecular Biology·Yusuke SaijoShigetaka Yasuda
Oct 30, 2020·International Journal of Molecular Sciences·Julien Lang, Jean Colcombet
Jan 1, 2021·Frontiers in Plant Science·Steven DreischhoffAndrea Polle
Jan 21, 2021·International Journal of Molecular Sciences·Peter S MillardMeike Burow
May 20, 2021·Nature Plants·Benjamin A MaierJulia A Vorholt
Jan 12, 2019·Journal of Proteome Research·Tong ZhangSixue Chen

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