Phosphorylation of tubulin enhances its interaction with membranes

Nature
A J HargreavesJ Avila

Abstract

Tubulin, the main component of intracellular microtubules, is also a major protein in subcellular membrane preparations and can interact with biological and artificial membranes in vitro. Of particular interest is the association of tubulin with postsynaptic junctional lattices enriched in a polypeptide of relative molecular mass (Mr) 50,000 (50K), recently identified as the major subunit of the calmodulin-dependent protein kinase. Phosphorylation of tubulin with a calmodulin-dependent protein kinase similar to that found in postsynaptic densities inhibits its ability to self-assemble into microtubules in a reversible fashion. This involves the phosphorylation of residues in its 4K carboxy-terminal region, a domain that seems to regulate its self-assembly. The results presented here suggest that the phosphorylation of tubulin with this kinase enhances its ability to interact with membranes. This effect is reversible.

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A Helenius, K Simons
May 5, 1979·Brain Research·C A MarottaJ M Gilbert
Jun 1, 1979·The Journal of Cell Biology·J M Caron, R D Berlin
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Oct 9, 1975·Nature·B B Walters, A I Matus
Dec 16, 1985·European Journal of Biochemistry·L SerranoJ Avila
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M L ShelanskiC R Cantor
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L SerranoJ Avila
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M B KennedyN E Erondu
Nov 1, 1980·Journal of Neurochemistry·D Soifer, H Czosnek

❮ Previous
Next ❯

Citations

Jan 1, 1992·Cell Motility and the Cytoskeleton·C D Rasmussen, A R Means
Apr 7, 1993·Molecular and Cellular Biochemistry·C RiscoJ L Carrascosa
Jan 1, 1987·The Journal of Membrane Biology·V Niggli, M M Burger
Jan 1, 1989·Molecular Neurobiology·C O Van HooffW H Gispen
Jan 1, 1992·Life Sciences·J Avila
Apr 1, 1990·Virus Research·A GregoriadesE Paoletti
Nov 13, 2002·Experimental Parasitology·Beatriz CasasMary I Gonzatti
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T SeebeckM Müller
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S S Matsuyama, L F Jarvik
Oct 1, 1987·The Journal of Cell Biology·L SerranoJ Avila
Mar 1, 1997·European Journal of Biochemistry·T H MacRae
Jul 1, 1990·Molecular Reproduction and Development·T Bloom, J McConnell
Sep 1, 1996·Neurochemical Research·J R Lagnado, E Kirazov
Jun 1, 1989·Bioscience Reports·A J HargreavesJ Avila
Oct 1, 1986·Bioscience Reports·A J Hargreaves, J Avila
Feb 29, 2020·Nature Reviews. Molecular Cell Biology·Carsten Janke, Maria M Magiera
Aug 1, 1998·The Journal of Biological Chemistry·C V CarmanJ L Benovic
Jun 1, 1988·The American Journal of Physiology·C M SzegoF S Sjöstrand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.