Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yukio SasakiGary J Bassell

Abstract

The localization of specific mRNAs and their local translation in growth cones of developing axons has been shown to play an important mechanism to regulate growth cone turning responses to attractive or repulsive cues. However, the mechanism whereby local translation and growth cone turning may be controlled by specific mRNA-binding proteins is unknown. Here we demonstrate that brain-derived neurotrophic factor (BDNF) signals the Src-dependent phosphorylation of the beta-actin mRNA zipcode binding protein 1 (ZBP1), which is necessary for beta-actin synthesis and growth cone turning. We raised a phospho-specific ZBP1 antibody to Tyr396, which is a Src phosphorylation site, and immunofluorescence revealed BDNF-induced phosphorylation of ZBP1 within growth cones. The BDNF-induced increase in fluorescent signal of a green fluorescent protein translation reporter with the 3' untranslated region of beta-actin was attenuated with the Src family kinase-specific inhibitor PP2 [4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine]. Furthermore, a nonphosphorylatable mutant, ZBP1 Y396F, suppressed the BDNF-induced and protein synthesis-dependent increase in beta-actin localization in growth cones. Last, the ZBP1 Y396F mutant b...Continue Reading

References

Apr 3, 2001·Annual Review of Neuroscience·O Steward, E M Schuman
Jan 16, 2003·Current Biology : CB·Lionel ArnaudJonathan A Cooper
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Michael Piper, Christine Holt
Dec 17, 2004·Biology of the Cell·Joel K Yisraeli
Nov 25, 2005·Nature·Ralf Dahm, Michael Kiebler
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ulrich HengstSamie R Jaffrey
Sep 19, 2006·Nature Neuroscience·Kin-Mei LeungChristine E Holt
Sep 20, 2006·Neuron·Michael A Kiebler, Gary J Bassell
Oct 5, 2006·Cell·Michael A Sutton, Erin M Schuman
Jan 9, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander K MurashovMichael R Van Scott
May 8, 2007·Trends in Biochemical Sciences·Joel D Richter
Jul 31, 2007·The EMBO Journal·Andrew C Lin, Christine E Holt
Sep 13, 2007·Nature Reviews. Neuroscience·Clive R Bramham, David G Wells
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Usha NarayananStephen T Warren
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ingrid BureauKarel Svoboda
Feb 26, 2009·Cell·Kelsey C Martin, Anne Ephrussi
Apr 8, 2009·Nature Methods·Philip J SantangeloJames E Crowe

❮ Previous
Next ❯

Citations

Jul 20, 2012·Histochemistry and Cell Biology·Reena RathodMichael Sendtner
Mar 10, 2011·Nature Reviews. Neuroscience·Takuro TojimaHiroyuki Kamiguchi
Apr 14, 2012·Nature Reviews. Neuroscience·Hosung JungChristine E Holt
Oct 2, 2013·The Journal of Cell Biology·Toshiaki ShigeokaChristine E Holt
May 30, 2012·Human Molecular Genetics·Claudia FalliniWilfried Rossoll
Jan 8, 2013·Nucleic Acids Research·Svetlana A ShabalinaAnna Kashina
Jan 27, 2012·Genes & Development·Nadine StöhrStefan Hüttelmaier
Jan 14, 2012·Learning & Memory·Kyle A B LapidusKevin Czaplinski
Apr 24, 2012·PloS One·Marcello CeciAntonino Cattaneo
Aug 23, 2012·PloS One·Almudena Pacheco, Jeffery L Twiss
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristy Welshhans, Gary J Bassell
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J DonnellyJeffery L Twiss
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vijayalaxmi C NalavadiGary J Bassell
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard P C MannsRoger J Keynes
Aug 23, 2012·F1000 Biology Reports·Graydon B Gonsalvez, Roy M Long
Oct 11, 2011·Cellular and Molecular Life Sciences : CMLS·Karen Shahbabian, Pascal Chartrand
Oct 18, 2015·Journal of Molecular Neuroscience : MN·Z LestanovaJ Bakos
Sep 1, 2015·PloS One·Michal Shoshkes CarmelJoel K Yisraeli
Nov 1, 2015·Developmental Neurobiology·Shruti Jain, Kristy Welshhans
Aug 8, 2009·Molecular and Cellular Neurosciences·Fabienne E Poulain, André Sobel
Jan 10, 2012·Neurochemistry International·Qian ChenZheng-ping Yu
Mar 31, 2005·Molecular and Cellular Neurosciences·María José Martínez-LópezCarlos Buesa
Oct 11, 2008·Journal of Theoretical Biology·Matthew O'TooleKyle E Miller
Jan 27, 2007·Current Opinion in Neurobiology·Jennifer Round, Elke Stein
Apr 30, 2011·Progress in Neurobiology·Daniel M Suter, Kyle E Miller
Jul 14, 2011·Acta Biochimica Et Biophysica Sinica·John R Sinnamon, Kevin Czaplinski
Feb 23, 2012·Scientific Reports·Bin MaNaoko Tanese
Mar 1, 2017·Developmental Neurobiology·Leah Kershner, Kristy Welshhans
Feb 2, 2017·Cell Reports·Giuseppe NicastroAndres Ramos
Apr 12, 2018·Biological Chemistry·Fabienne De Graeve, Florence Besse
Sep 1, 2011·The EMBO Journal·Michael Doyle, Michael A Kiebler
Oct 4, 2011·The EMBO Journal·Christopher J DonnellyJeffery L Twiss
Jan 17, 2019·American Journal of Physiology. Cell Physiology·Li-Ping JiangJaladanki N Rao
Nov 13, 2013·Nature Reviews. Neurology·Jami Scheib, Ahmet Höke
Jul 31, 2013·Developmental Neurobiology·Yukio SasakiGary J Bassell
Jun 18, 2019·Traffic·Nadia FormicolaFlorence Besse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.