Phosphorylation regulates calpain-mediated truncation of glutamate ionotropic receptors

Brain Research
R BiM Baudry

Abstract

Pre-incubation of synaptic membranes with phosphatase inhibitors significantly reduces the extent of calpain-mediated truncation of both GluR1 and NR2 subunits of AMPA and NMDA receptors, respectively. The same treatment did not modify calpain-mediated truncation of spectrin. These results might have important implications for mechanisms of synaptic plasticity as the balance of kinase/phosphatase activity and calpain has been proposed to regulate synaptic efficacy at glutamatergic synapses.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Shahi, M Baudry
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·I S MoonM B Kennedy
Oct 1, 1994·Trends in Neurosciences·J Lisman
Mar 18, 1994·Brain Research. Developmental Brain Research·J S Fitzpatrick, M Baudry
Jun 1, 1994·Current Opinion in Neurobiology·K W RocheR L Huganir
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Ambros-Ingerson, G Lynch
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MarenR F Thompson
Aug 1, 1996·Current Opinion in Cell Biology·M D EhlersR L Huganir

❮ Previous
Next ❯

Citations

Aug 8, 2008·Molecular Neurobiology·P S VoslerJ Chen
Apr 25, 2002·Molecular and Cellular Biology·Gaël NicolasMarie-Christine Lecomte
May 26, 2009·Neural Development·Timothy P O'ConnorShernaz X Bamji
Jul 5, 2008·Molecular and Cellular Neurosciences·Ildikó VilágiPeter Friedrich
Apr 20, 2004·European Journal of Pharmacology·Francois TrudeauGuy Massicotte
Jan 15, 2014·Neuropharmacology·Shireen HossainGuillermina Almazan
Jan 29, 2017·Biochimica Et Biophysica Acta. General Subjects·Ana SaavedraEsther Pérez-Navarro
Sep 13, 2001·Journal of Neurochemistry·R P GuttmannD R Lynch
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Rodney P GuttmannDavid R Lynch
Nov 26, 2002·The Journal of Biological Chemistry·Jonathan H NedrelowJon S Morrow
Sep 28, 2018·Medicinal Research Reviews·Yacoubou Abdoul Razak MahamanXiaochuan Wang
Jan 1, 2012·ISRN Biochemistry·Adriana Ferreira
Apr 10, 2008·Science Signaling·Jing LiuKevin K W Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.