Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events

Experimental Biology and Medicine
Shenq-Shyang Huang, Nan-Shan Chang

Abstract

Abnormal differentiation and growth of hematopoietic stem cells cause the development of hematopoietic diseases and hematopoietic malignancies. However, the molecular events underlying leukemia development are not well understood. In our recent study, we have demonstrated that calcium ionophore and phorbol ester force the differentiation of T lymphoblastic leukemia. The event involves a newly identified IκBα/WWOX/ERK signaling, in which WWOX is Ser14 phosphorylated. Additional evidence also reveals that pS14-WWOX is involved in enhancing cancer progression and metastasis and facilitating neurodegeneration. In this mini-review, we update the current knowledge for the functional roles of WWOX under physiological and pathological settings, and provide new insights regarding pS14-WWOX in T leukemia cell maturation, and switching the anticancer pY33-WWOX to pS14-WWOX for cancer promotion and disease progression. Impact statement WWOX was originally designated as a tumor suppressor. However, human newborns deficient in WWOX do not spontaneously develop tumors. Activated WWOX with Tyr33 phosphorylation is present in normal tissues and organs. However, when pY33-WWOX is overly induced under stress conditions, it becomes apoptotic to el...Continue Reading

References

Dec 1, 1994·Trends in Biochemical Sciences·P Bork, M Sudol
Jan 20, 1997·The Journal of Experimental Medicine·H Kishimoto, J Sprent
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Dec 29, 1998·Cell·M D Jacobs, S C Harrison
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T Hettmann, J M Leiden
Feb 13, 2001·Cell·M Sudol, T Hunter
Nov 28, 2001·The Journal of Biological Chemistry·Pei-Jung LuKun Ping Lu
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Jan 7, 2003·The Journal of Biological Chemistry·Nan-Shan ChangAmy Ensign
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Oct 14, 2003·Biochemical Pharmacology·Nan-Shan ChangUdo Oppermann
Mar 5, 2004·Proteomics·Hai HuJuan J Herrero
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rami I AqeilanCarlo M Croce
Jun 1, 2004·International Journal of Hematology·Hideshi Ishii, Yusuke Furukawa
Feb 5, 2005·Breast Cancer Research and Treatment·María I NunezC Marcelo Aldaz
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Feng-Jie LaiHamm-Ming Sheu
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Flávio J PimentaRicardo S Gomez
Dec 20, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E PłuciennikA K Bednarek
Jan 6, 2006·IUBMB Life·Marius SudolAmjad Farooq
Jan 28, 2006·Biochemical and Biophysical Research Communications·Changjiang JinXuebiao Yao
Mar 11, 2006·Cell Death and Differentiation·V BotteroI M Verma
Jul 5, 2006·Cancer Research·Haiyan R QinKay Huebner
Dec 5, 2006·Trends in Molecular Medicine·Nan-Shan ChangHamm-Ming Sheu
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dimitrios IliopoulosKay Huebner
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rami I AqeilanCarlo M Croce
Jun 19, 2007·Cancer Research·Rami I AqeilanCarlo M Croce
Sep 8, 2007·Genes, Chromosomes & Cancer·John H Ludes-MeyersC Marcelo Aldaz

❮ Previous
Next ❯

Citations

Mar 28, 2018·Cell Death Discovery·Hsiang-Ling KuoNan-Shan Chang
Feb 13, 2019·Translational Neuroscience·Salleh N EhaidebMajid Alfadhel
Aug 31, 2018·Frontiers in Neuroscience·Chan-Chuan LiuNan-Shan Chang
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Ying-Tsen ChouLi-Jin Hsu
May 6, 2021·Cells·Karim TaouisFrançois Lallemand
Aug 8, 2021·Cells·Che-Yu HsuNan-Shan Chang

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
ubiquitination
gene
co-immunoprecipitation
two-hybrid

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved