Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

Scientific Reports
Tommaso De MarchiJohn W M Martens

Abstract

In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease. We here aimed to study the association of PSAT1 protein levels to outcome upon tamoxifen treatment and to obtain more insight in its role in tamoxifen resistance. A cohort of ER positive, hormonal therapy naïve primary breast carcinomas was immunohistochemically (IHC) stained for PSAT1. Staining was analyzed for association with patient's time to progression (TTP) and overall response on first-line tamoxifen for recurrent disease. PSAT1 mRNA levels were also assessed by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR; n = 161) and Affymetrix GeneChip (n = 155). Association of PSAT1 to biological pathways on tamoxifen outcome were assessed by global test. PSAT1 protein and mRNA levels were significantly associated to poor outcome to tamoxifen treatment. When comparing PSAT1 protein and mRNA levels, IHC and RT-qPCR data showed a significant association. Global test results showed that cytokine and JAK-STAT signaling were associated to PSAT1 expression. We hereby report that PSAT1 protein and mRNA levels measured i...Continue Reading

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Citations

Mar 7, 2019·Frontiers in Pharmacology·Emma CazalyJing Tang
Jan 26, 2020·Experimental & Molecular Medicine·Elizabeth L LieuJiyeon Kim
Aug 28, 2020·Frontiers in Oncology·Susana Romero-GarciaAngeles Carlos-Reyes
Apr 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annemarie E M PostPaul N Span
Aug 1, 2021·Chemico-biological Interactions·Alok MishraAshutosh Shrivastava
Aug 25, 2021·Technology in Cancer Research & Treatment·Qian ZhangHuanliang Liu

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Datasets Mentioned

BETA
GSE7390
GSE11121
GSE82173

Methods Mentioned

BETA
chip
PCR

Software Mentioned

Affymetrix
Stata
fRMA
Slidepath
GraphPad
R
ComBat
Excel

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