Photo-acoustic excitation and optical detection of fundamental flexural guided wave in coated bone phantoms

Ultrasound in Medicine & Biology
Petro MoilanenJussi Timonen

Abstract

Photo-acoustic (PA) imaging was combined with skeletal quantitative ultrasound (QUS) for assessment of human long bones. This approach permitted low-frequency excitation and detection of ultrasound so as to efficiently receive the thickness-sensitive fundamental flexural guided wave (FFGW) through a coating of soft tissue. The method was tested on seven axisymmetric bone phantoms, whose 1- to 5-mm wall thickness and 16-mm diameter mimicked those of the human radius. Phantoms were made of a composite material and coated with a 2.5- to 7.5-mm layer of soft material that mimicked soft tissue. Ultrasound was excited with a pulsed Nd:YAG laser at 1064-nm wavelength and received on the same side of the coated phantom with a heterodyne interferometer. The FFGW was detected at 30-kHz frequency. Fitting the FFGW phase velocity by the FLC(1,1) tube mode provided an accurate (9.5 ± 4.0%) wall thickness estimate. Ultrasonic in vivo characterization of cortical bone thickness may thus become possible.

References

Jun 1, 2000·The Journal of the Acoustical Society of America·I NunezM Fink
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H H Bolotin, H Sievänen
Jul 13, 2002·Journal of Biomedical Materials Research·F LefebvreJ J Fabre
Jul 27, 2002·The Journal of the Acoustical Society of America·Emmanuel BossyPascal Laugier
Nov 27, 2002·Physiological Measurement·Patrick H F NicholsonSulin Cheng
Jan 28, 2003·Biophysical Journal·Erwin J G PetermanChristoph F Schmidt
Apr 10, 2003·Journal of Biomedical Optics·Barry P PayneNorman S Nishioka
Apr 10, 2003·Journal of Biomedical Optics·Barry P PayneNorman S Nishioka
Oct 18, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P MoilanenS Cheng
Mar 5, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emmanuel BossyPascal Laugier
May 14, 2004·The Journal of the Acoustical Society of America·Emmanuel BossyPascal Laugier
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emmanuel BossyPascal Laugier
Jun 29, 2005·Ultrasonics·Alexey TatarinovArmen Sarvazyan
Sep 24, 2005·Ultrasound in Medicine & Biology·Kay RaumPascal Laugier
May 9, 2006·Ultrasound in Medicine & Biology·P MoilanenJ Timonen
Sep 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pekka KannusMarkku Järvinen
Feb 20, 2007·Ultrasound in Medicine & Biology·Petro MoilanenJussi Timonen
Oct 2, 2007·The Journal of the Acoustical Society of America·Petro MoilanenPascal Laugier
Oct 12, 2007·The Journal of the Acoustical Society of America·Petro MoilanenPascal Laugier
Jul 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Petro Moilanen
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·C C Gluer
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·D Hans, M A Krieg
Dec 10, 2008·The Journal of the Acoustical Society of America·Petro MoilanenPascal Laugier
Sep 3, 2009·Physics in Medicine and Biology·Changhui Li, Lihong V Wang
Feb 18, 2010·Nature Photonics·Lihong V Wang
May 13, 2010·Journal of Biomedical Optics·Daniel M de BruinDirk J Faber
Jun 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V KilappaS Cheng
Dec 2, 2010·The Journal of the Acoustical Society of America·Jean-Gabriel MinonzioPascal Laugier
Mar 25, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Amit ShelkeWolfgang Grill
Jun 16, 2011·Lasers in Surgery and Medicine·Masato SatoJoji Mochida

❮ Previous
Next ❯

Citations

May 13, 2014·The Journal of the Acoustical Society of America·Ludovic MoreauPascal Laugier
Mar 20, 2015·The Journal of the Acoustical Society of America·Vantte KilappaJussi Timonen
Jan 27, 2015·The Journal of the Acoustical Society of America·Jean-Gabriel MinonzioPascal Laugier
Oct 22, 2015·Journal of Biophotonics·Idan SteinbergAvishay Eyal
Jul 23, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Kailiang XuPascal Laugier
Mar 4, 2017·Scientific Reports·Nicolas BochudPascal Laugier
Mar 2, 2017·Physics in Medicine and Biology·Héctor EstradaDaniel Razansky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.