Photo-activated DNA binding and antimicrobial activities of furoquinoline and pyranoquinolone alkaloids from rutaceae

Planta medica
Fujinori HanawaAlexios-Leandros Skaltsounis

Abstract

To find novel photo-active compounds of potential use in photochemotherapy from higher plants, photo-activated antimicrobial and DNA binding activities of the furoquinolines, skimmianine, kokusaginine, and haplopine, and a pyranoquinolone, flindersine, from two species of Rutaceae plants were investigated. TLC overlay assays against a methichillin-resistant strain of Staphylococcus aureus and Candida albicans were employed to test antimicrobial properties. All of the tested compounds showed photo-activated antimicrobial activity against S. aureus in the order of kokusaginine > haplopine, flindersine > skimmianine. Weaker activity was found for C. albicans. Photo-activated DNA binding activity of these compounds was investigated by a method using restriction enzymes and a specially designed 1.5 kb DNA fragment. Kokusaginine showed inhibition against all of the 16 restriction enzymes. Haplopine showed a similar inhibition pattern but the binding activity against Asc I and Sma I with restriction sequences consisting only of G and C was very weak. Skimmianine showed binding activity against Xba I, BciV I, Sal I, Pst I, Sph I and Hind III, but very weak or no activity was found for the other restriction enzymes. A pyranoquinolone, f...Continue Reading

Citations

Sep 30, 2005·Natural Product Reports·Joseph P Michael
Sep 15, 2009·International Journal of Antimicrobial Agents·F O'DonnellW F Smyth
Sep 14, 2017·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Jan 15, 2021·Bioorganic & Medicinal Chemistry·Basavarajaiah Suliphuldevara MatadaNagesh Gunavanthrao Yernale
Jan 12, 2007·The Journal of Physical Chemistry. a·Pier Luigi GentiliGianna Favaro

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