Photo-based External Quality Assessment of Malaria rapid diagnostic tests in a non-endemic setting

PloS One
Kris VernelenJan Jacobs

Abstract

In non-endemic settings, expertise in malaria microscopy is limited and rapid diagnostic tests (RDTs) are an adjunct to malaria diagnosis. We performed an External Quality Assessment (EQA) on reading and interpretation of malaria RDTs in a non-endemic setting. Participants were medical laboratories in Belgium and the Grand Duchy of Luxembourg using malaria RDTs; they received (i) 10 high-resolution photographs presenting test line combinations of RDTs with interpretations listed in a multiple choice format and (ii) a questionnaire about their practices of malaria diagnosis. Among 135 subscribing laboratories, 134 (99.3%) used 139 RDT products (11 different products from 8 brands). After exclusion of the results of one laboratory, analysis was done for 133 laboratories using 137 RDT products. Scores of 10/10, 9/10 and 8/10 were achieved for 58.4%, 13.1% and 8.0% of 137 RDT products respectively. For three-band P. falciparum-pan-Plasmodium RDTs (113 (82.5%) products, 6 brands), most frequent errors were (1) disregarding faint test lines (18.6%), (2) reporting invalid instead of P. falciparum (16.8%) and (3) reporting "Plasmodium spp., no further differentiation possible" without mentioning the presence or absence of P. falciparum...Continue Reading

References

Jan 10, 2002·Clinical Microbiology Reviews·Anthony Moody
Jul 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T Hänscheid
Oct 7, 2004·Annals of Internal Medicine·Robert D NewmanRichard W Steketee
Apr 11, 2006·Journal of Clinical Pathology·D ChiltonP L Chiodini
Oct 20, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Waverly RennieSteven Harvey
Apr 27, 2007·Trends in Parasitology·Ivo MuellerJohn C Reeder
Jan 19, 2008·Clinical Microbiology Reviews·Clinton K MurrayR Scott Miller
Oct 20, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F Moulin, D Gendrel
Dec 2, 2009·Malaria Journal·Philippe GilletJan Jacobs
Jan 7, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ulf BronnerBirgitta Evengård
Jun 17, 2011·Malaria Journal·Philippe GilletJan Jacobs
Jun 22, 2012·Journal of Clinical Microbiology·Michael A DimaioNiaz Banaei
Sep 19, 2012·Malaria Journal·Helena H AsklingUNKNOWN European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology
Nov 9, 2012·Journal of Clinical Microbiology·April BobenchikRomney M Humphries
Feb 5, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MalthaJ Jacobs
Feb 27, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MalthaJ Jacobs
Nov 14, 2013·British Journal of Haematology·J Wendi BaileyUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
Mar 17, 2015·Journal of Infection in Developing Countries·Lurdes SantosAntónio Sarmento
Apr 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B Millar, J Cox-Singh
Feb 18, 2016·The Journal of Infection·David G LallooUNKNOWN PHE Advisory Committee on Malaria Prevention in UK Travellers
Feb 2, 2017·Malaria Journal·Florian KurthThomas Zoller

❮ Previous
Next ❯

Software Mentioned

SD
Excel
PALUTOP

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.