Photo-Irresponsive Molecule-Amplified Cell Release on Photoresponsive Nanostructured Surfaces

ACS Applied Materials & Interfaces
Guannan LiShutao Wang

Abstract

Cell manipulation has raised extensive concern owing to its underlying applications in numerous biological situations such as cell-matrix interaction, tissue engineering, and cell-based diagnosis. Generally, light is considered as a superior candidate for manipulating cells (e.g., cell release) due to their high spatiotemporal precision and non-invasion. However, it remains a big challenge to release cells with high efficiency due to their potential limitation of the light-triggered wettability transition on photoresponsive surfaces. In this study, we report a photoresponsive spiropyran-coated nanostructured surface that enables highly efficient release of cancer cells, amplified by the introduction of a photo-irresponsive molecule. On one hand, structural recognition stems from topological interaction between nanofractal surfaces and the protrusions of cancer cells. On the other, molecular recognition can be amplified by a photo-irresponsive and hydrophilic molecule by reducing the steric hindrance of photoresponsive components and resisting nonspecific cell adhesion. Therefore, this study may afford a novel avenue for developing advanced smart materials for high-quality biological analysis and clinical diagnosis.

References

Jan 8, 2004·Journal of the American Chemical Society·Xinjian FengDaoben Zhu
Mar 15, 2005·Biomacromolecules·Jun-Ichi EdahiroYasuo Yoshimi
Jul 16, 2005·Angewandte Chemie·Xinjian FengLei Jiang
Jul 26, 2012·Angewandte Chemie·Clara BriekeAlexander Heckel
Sep 20, 2012·Angewandte Chemie·Young-Jin KimTakao Aoyagi
Aug 28, 2013·Chemical Society Reviews·Rafal Klajn
Jan 29, 2014·Journal of the American Chemical Society·Wen LiXiaogang Qu
Feb 8, 2014·Chemical Society Reviews·Xueli Liu, Shutao Wang
Apr 9, 2014·Nature Communications·Pintu K KunduRafal Klajn
Sep 30, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yin-Ning ZhouZheng-Hong Luo
Feb 13, 2018·Nature Materials·Thomas C von ErlachMolly M Stevens
Mar 16, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yuwei HaoShutao Wang
May 18, 2018·Nature·Christopher M MadlHelen M Blau
Jun 8, 2018·Chemical Society Reviews·Jianming PanGuoqing Pan
Jun 14, 2018·Nature Communications·Stephen G ParkerJ Justin Gooding
Oct 5, 2018·Nature Communications·Silvia A FerreiraEileen Gentleman
Oct 5, 2018·Chemical Society Reviews·Wen LiXiaogang Qu

❮ Previous
Next ❯

Citations

Jun 17, 2021·Journal of Bionic Engineering·Shuyi LiLuquan Ren

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved