Photo-oxidation of ergosterol: indirect detection of antioxidants photosensitizers or quenchers of singlet oxygen

Journal of Photochemistry and Photobiology. B, Biology
Irene Lagunes, Ángel Trigos

Abstract

Consumption of antioxidant supplements is associated to prevention of several diseases. However, recent studies suggest that antioxidants, besides scavenge free radicals could lead development of tumors. Due to conflicting reports on the antioxidant benefits, the capacity to photosensitize the generation of singlet oxygen of seven natural antioxidants was evaluated through photo-oxidation of ergosterol which proved to be an efficient method of indirect detection of singlet oxygen. Our results showed that curcumin, resveratrol and quercetin have pro-oxidant activity due they act as photosensitizers in generation of singlet oxygen. In addition, we observed that genistein, naringenin, β-carotene and gallic acid besides their antioxidant activity against ROS radicals, are capable of quenching ROS non-radicals as singlet oxygen. Finally, our results allow us to propose a new approach in classification of natural antioxidants scavengers of free radicals, based on their activity as quenchers of singlet oxygen or as photosensitizers in singlet oxygen generation.

References

Dec 16, 1998·The British Journal of Nutrition·A T DiplockJ Viña-Ribes
Mar 11, 2000·European Journal of Biochemistry·T BöckingM Höfer
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jean-Francois MarierMurray P Ducharme
Aug 19, 2003·Archives of Biochemistry and Biophysics·Kaeko Murota, Junji Terao
Aug 31, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas WalleU Kristina Walle
Jul 31, 2010·Journal of Agricultural and Food Chemistry·Chiu-Lan HsiehRobert Y Peng
Dec 24, 2010·The Journal of Nutrition·Regan L BaileyMary Frances Picciano
Oct 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·A AmriC Charrueau
Jun 13, 2012·Oxidative Medicine and Cellular Longevity·Sebastiano CiminoGiuseppe Morgia
Jul 11, 2012·Journal of Toxicology·Brigitte GonthierLuc Barret
Jan 8, 2013·European Journal of Medicinal Chemistry·Claudriana LocatelliTânia Beatriz Creczynski-Pasa
Oct 22, 2013·European Journal of Medicinal Chemistry·Klaudia Jomova, Marian Valko
Jan 31, 2014·Science Translational Medicine·Volkan I SayinMartin O Bergo
Oct 14, 2014·Food Chemistry·Yue ZhaoYue-Rong Liang

❮ Previous
Next ❯

Citations

Oct 31, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maja KozarskiLeo van Griensven
Apr 30, 2016·Chemical Reviews·Ashwini A Ghogare, Alexander Greer
Aug 26, 2017·Journal of Food Science·Irene LagunesÁngel Trigos
Mar 6, 2019·International Journal of Molecular Sciences·Hilde Harb BuzzáCristina Kurachi
Sep 29, 2018·Scientific Reports·César EspinozaJosé J Fernández

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.