Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in Wistar rats.

Indian Journal of Dermatology
Arun G MaiyaShivanand Nayak

Abstract

Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood. We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model. The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9 J/cm(2) for 5 days a week until the wounds healed completely. The control group was sham irradiated. A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation. The biochemical analysis and clinical observation suggested that 3-6 J/cm(2) laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.

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Citations

Apr 9, 2010·Photomedicine and Laser Surgery·James D Carroll
Oct 13, 2012·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Maria Stella PeccinDaniel Araki Ribeiro
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Elisabetta MerigoPaolo Vescovi
Sep 22, 2016·Lasers in Medical Science·Melyssa Lima de MedeirosMaria Aparecida Medeiros Maciel
Sep 1, 2016·Anais Brasileiros De Dermatologia·Raquel Gomes de Sousa, Keila de Nazaré Madureira Batista
May 12, 2016·Acta Cirúrgica Brasileira·Reza Ranjbar, Mohammad Ashrafzadeh Takhtfooladi
Jun 12, 2014·Revista do Colégio Brasileiro de Cirurgiões·Fabiana do Socorro da Silva Dias AndradeManoel Luiz Ferreira
Dec 18, 2018·Journal of Wound Care·Arun G MaiyaLaxmikant G Keni
Oct 27, 2017·Journal of Lasers in Medical Sciences·Maryam YousefLadan Hassani
Nov 22, 2017·Lasers in Medical Science·Stheace Kelly Fernandes SzezerbatyRegina Célia Poli-Frederico
Apr 20, 2021·Cell Biochemistry and Function·Olajumoke OyebodeHeidi Abrahamse

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