Photo-thermal effect enhances the efficiency of radiotherapy using Arg-Gly-Asp peptides-conjugated gold nanorods that target αvβ3 in melanoma cancer cells

Journal of Nanobiotechnology
Ping LiShen Fu

Abstract

Thermotherapy has been known to be one of the most effective adjuvants to radiotherapy (RT) in cancer treatment, but it is not widely implemented clinically due to some limitations, such as, inadequate temperature concentrations to the tumor tissue, nonspecific and non-uniform distribution of heat. So we constructed arginine-glycine-aspartate peptides-conjugated gold nanorods (RGD-GNRs) that target the alpha(v) beta(3) Integrin (αvβ3) and investigate whether the photo-thermal effect of RGD-GNRs by near infrared radiation (NIR) could enhance the efficiency of RT in melanoma cancer cells. RGD-GNRs could be seen both on the surface of the cell membranes and cytoplasm of A375 cells with high expression of αvβ3. After exposed to 808 nm NIR, RGD-GNRs with various concentrations could be rapidly heated up. Compared to other treatments, flow cytometric analysis indicated that RT + NIR + RGD-GNRs increased apoptosis (p < 0.001) and decreased the proportion of cells in the more radioresistant S phase (p = 0.014). Treated with NIR + RGD-GNRs, the radiosensitivity was also significantly enhanced (DMFSF2: 1.41). Results of the current study showed the feasibility of using RGD-GNRs for synergetic RT with photo-thermal therapy. And it would g...Continue Reading

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Citations

Mar 25, 2017·International Journal of Cancer. Journal International Du Cancer·Jian-Qin TangGuan Jiang
Mar 2, 2018·Lasers in Medical Science·Hasan NorouziFatemeh Akbarzadeh
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Aug 30, 2018·Advanced Materials·Jiani XieYuliang Zhao
Jan 30, 2020·Anti-cancer Agents in Medicinal Chemistry·Mousa TabeiAli Shakeri-Zadeh
Oct 11, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Habib GhaznaviAlireza Montazerabadi
Jun 12, 2019·Bioinorganic Chemistry and Applications·Nthabeleng HlapisiSandile P Songca
Sep 12, 2019·Advanced Science·Minho KimJwa-Min Nam
Oct 10, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M MirrahimiS M A Hosseini Nami
Sep 12, 2018·Radiation and Environmental Biophysics·Ali NeshastehrizAli Shakeri-Zadeh
Jul 1, 2020·International Journal of Radiation Biology·Georgios KareliotisAlexandros G Georgakilas
May 12, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·María Pedrosa-RiveraCarmen Ruiz-Ruiz
Oct 20, 2017·Chemical Reviews·Wenpei FanXiaoyuan Chen

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Methods Mentioned

BETA
surface plasmon resonance
X-ray
flow cytometry
transmission electron microscopy

Software Mentioned

multicycle system
Graphpad Prism

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