Photoacoustic imaging of carotid artery atherosclerosis

Journal of Biomedical Optics
Pieter KruizingaGijs van Soest

Abstract

We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection of lipid-rich atherosclerotic lesions. A common human carotid artery was obtained at autopsy, embedded in a neck mimicking phantom and imaged with a multimodality imaging system using interstitial illumination. Light was delivered through a 1.25-mm-diameter optical probe that can be placed in the pharynx, allowing the carotid artery to be illuminated from within the body. Ultrasound imaging and photoacoustic signal detection is achieved by an external 8-MHz linear array coupled to an ultrasound imaging system. Spectroscopic analysis of photoacoustic images obtained in the wavelength range from 1130 to 1250 nm revealed plaque-specific lipid accumulation in the collagen structure of the artery wall. These spectroscopic findings were confirmed by histology.

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Citations

Jun 28, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Liyang Cui, Jianghong Rao
May 27, 2016·PloS One·Mazen A JuratliVladimir P Zharov
Jul 10, 2017·Journal of Vascular Research·Bing LiYuyu Yao
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Mar 25, 2018·Journal of Biomedical Optics·Mucong LiJunjie Yao
Dec 23, 2016·Journal of Biomedical Optics·Mustafa Umit ArabulRichard G P Lopata
May 3, 2019·Physics in Medicine and Biology·Sophinese Iskander-RizkGijs van Soest
Oct 31, 2018·Technology in Cancer Research & Treatment·Jing MengLiang Song
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May 30, 2019·Biomedical Engineering Online·Ashish SaxenaSoo Teik Lim
Jul 26, 2019·Physics in Medicine and Biology·Xosé Luís Deán-Ben, Daniel Razansky
Dec 29, 2020·Journal of Lipid Research·Astrid M MoermanGijs Van Soest
Feb 14, 2021·Journal of Lipid Research·Astrid M MoermanGijs Van Soest
Apr 16, 2021·Photoacoustics·Sophinese Iskander-RizkGijs Van Soest
Aug 18, 2021·Photoacoustics·Xi YangMohamad Sawan
Aug 31, 2021·Biomedical Optics Express·Jan-Willem MullerRichard Lopata
Aug 12, 2021·British Journal of Pharmacology·Neil MacRitchiePasquale Maffia

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