Photoacoustic spectrum analysis for microstructure characterization in biological tissue: analytical model

Ultrasound in Medicine & Biology
Guan XuXueding Wang

Abstract

Photoacoustic spectrum (PA) analysis (PASA) has been found to have the ability to identify the microstructures in phantoms and biological tissues. PASA adopts the procedures in ultrasound spectrum analysis, although the signal generation mechanisms related to ultrasound backscatter and PA wave generation differ. The purpose of this study was to theoretically validate PASA. The analytical solution to the power spectrum of PA signals generated by identical microspheres following discrete uniform random distribution in space was derived. The simulation and experiment validation of the analytical solution include: (i) the power spectrum profile of a single microsphere with a diameter of 300 μm, and (ii) the PASA parameters of the PA signals generated by randomly distributed microspheres 100, 200, 300, 400 and 500 μm in diameter, at concentrations of 30, 60, 120, 240, 480 per 1.5(3) cm(3) in the observation range 0.5-13 MHz.

References

Apr 1, 1983·The Journal of the Acoustical Society of America·F L LizziD J Coleman
Jan 1, 1987·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·F L LizziM M Yaremko
Mar 8, 2011·Ultrasound in Medicine & Biology·Ronald E KumonXueding Wang
May 17, 2011·The Journal of the Acoustical Society of America·Ratan K Saha, Michael C Kolios
Dec 14, 2012·Journal of Biomedical Optics·Eno HysiMichael C Kolios
Jul 5, 2013·Biophysical Journal·Eric M StrohmMichael C Kolios
May 13, 2014·Journal of Biomedical Optics·Michelle P PattersonWilliam M Whelan

❮ Previous
Next ❯

Citations

Nov 10, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Erwin AllesAdrien Desjardins
May 18, 2016·Ultrasound in Medicine & Biology·Verya DaeichinGijs van Soest
Jul 1, 2017·Biomedical Optics Express·Haonan ZhangGuan Xu
Oct 8, 2015·Journal of Biomedical Optics·Mallika PriyaKrishna Kishore Mahato
Mar 30, 2021·Photoacoustics·Mengjiao ZhangQian Cheng
Mar 4, 2018·Ultrasound in Medicine & Biology·Xiang ZhangXiaojun Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.