Photoacoustic thermal diffusion flowmetry.

Biomedical Optics Express
Adi Sheinfeld, Avishay Eyal

Abstract

Thermal Diffusion Flowmetry (TDF) (also called Heat Clearance Method or Thermal Clearance Method) is a longstanding technique for measuring blood flow or blood perfusion in living tissues. Typically, temperature transients and/or gradients are induced in a volume of interest and the temporal and/or spatial temperature variations which follow are measured and used for calculation of the flow. In this work a new method for implementing TDF is studied theoretically and experimentally. The heat deposition which is required for TDF is implemented photothermally (PT) and the measurement of the induced temperature variations is done by photoacoustic (PA) thermometry. Both excitation light beams (the PT and the PA) are produced by directly modulated 830 nm laser diodes and are conveniently delivered to the volume under test by the same optical fiber. The method was tested experimentally using a blood-filled phantom vessel and the results were compared with a theoretical prediction based on the heat and the photoacoustic equations. The fitting of a simplified lumped thermal model to the experimental data yielded estimated values of the blood velocity at different flow rates. By combining additional optical sources at different wavelengt...Continue Reading

References

Nov 1, 1986·Medical & Biological Engineering & Computing·M Nitzan, Y Mahler
Jun 1, 1985·Physics in Medicine and Biology·M NitzanY Mahler
Jul 1, 1995·The Journal of Burn Care & Rehabilitation·L AtilesC Baxter
Jun 8, 2007·The Journal of the Acoustical Society of America·B T CoxP C Beard
Nov 22, 2008·Journal of Biomedical Optics·Roy G M KolkmanTon G van Leeuwen
Nov 10, 2009·Journal of Biomedical Optics·Manojit Pramanik, Lihong V Wang
Mar 10, 2010·Journal of Biomedical Optics·Song Hu, Lihong V Wang
Apr 15, 2010·Optics Express·Adi SheinfeldAvishay Eyal
Jan 5, 2011·Journal of Biomedical Optics·Adi SheinfeldAvishay Eyal
Aug 3, 2011·Journal of Biomedical Optics·Junjie YaoLihong V Wang
Aug 7, 2012·Interface Focus·Paul Beard

❮ Previous
Next ❯

Citations

Feb 20, 2016·Scientific Reports·Joanna Brunker, Paul Beard
Jan 15, 2014·Laser & Photonics Reviews·Junjie Yao, Lihong V Wang
Dec 8, 2015·Photoacoustics·P J van den BergW Steenbergen
Oct 11, 2014·Photoacoustics·Junjie Yao, Lihong V Wang
May 3, 2015·Ultrasonic Imaging·Junjie YaoLihong V Wang
Mar 1, 2018·Journal of Biomedical Optics·Thore M BückingJoanna Brunker
Feb 10, 2016·Journal of Biomedical Optics·Pim J van den BergWiendelt Steenbergen
Sep 7, 2017·Journal of Biomedical Optics·Wei LiuJunjie Yao
Jan 4, 2019·Biomedical Engineering Letters·Wei Liu, Junjie Yao
Dec 3, 2013·Physical Review Letters·Lidai WangLihong V Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
Thermal Diffusion Flowmetry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.