Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy

Journal of Biomedical Optics
Yu-Hsin WangPai-Chi Li

Abstract

This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several micrometers, are not only echogenic but also can serve as drug-delivery vehicles. The gold nanorods are used to enhance the generation of both photoacoustic and photothermal signals. The optical absorption peak of the gold nanorods is tuned to 760 nm and is invariant after microbubble encapsulation. Dual-modality contrast enhancement is first described here, and the applications to cellular targeting and laser-induced thermotherapy in a phantom are demonstrated. Photoacoustic imaging can be used to monitor temperature increases during the treatment. The targeting capability of AuMBs was verified, and the temperature increased by 26°C for a laser power of 980 mW, demonstrating the potential of combined diagnosis and therapy with the dual-modality agent. Targeted photo- or acoustic-mediated delivery is also possible.

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Citations

Sep 26, 2014·BioMed Research International·Ai-Ho LiaoChih-Hung Wang
Dec 23, 2014·International Journal of Molecular Sciences·Dan WuHuabei Jiang
Jan 21, 2014·Academic Radiology·Sheng-Min LanRuey-Mo Lin
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Aug 8, 2017·International Journal of Molecular Sciences·Dario Livio LongoAlexander Oraevsky
Jan 18, 2020·Journal of Biomedical Science·Wei-Wen Liu, Pai-Chi Li
Mar 10, 2017·Chemical Society Reviews·X L Deán-BenD Razansky
Nov 12, 2020·International Journal of Molecular Sciences·Shao-Lun LuPai-Chi Li

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