Photoactivated polyprodrug nanoparticles for effective light-controlled Pt(iv) and siRNA codelivery to achieve synergistic cancer therapy.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Qingfei ZhangYubin Huang

Abstract

Endo/lysosomal escape and the subsequent controllable/precise release of drugs and genes are key challenges for efficient synergistic cancer therapy. Herein, we report a photoactivated polyprodrug nanoparticle system (PPNPsiRNA) centered on effective light-controlled codelivery of Pt(iv) prodrug and siRNA for synergistic cancer therapy. Under green-light irradiation, PPNPsiRNA can sustainedly generate oxygen-independent azidyl radicals to facilitate endo/lysosomal escape through the photochemical internalization (PCI) mechanism. Besides, concurrent Pt(ii) release and siRNA unpacking could occur in a controllable manner after the decomposition of Pt(iv), main chain shattering of photoactivated polyprodrug and the PPNPsiRNA disassociation. Based on these innovative features, excellent synergistic therapeutic efficacy of chemo- and RNAi therapies of PPNPsiBcl-2 could be achieved on ovarian cancer cells under light irradiation. The facile synthesized and prepared photoactivatable polyprodrug nanoparticle system provides a new strategy for effective gene/drug codelivery, where controllable endo/lysosomal escape and the subsequent drug/gene release/unpacking play vital roles, which could be adopted as a versatile codelivery nanoplatf...Continue Reading

References

Jan 7, 2004·Advanced Drug Delivery Reviews·Anders HøgsetKristian Berg
Jul 6, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pål Kristian SelboKristian Berg
Jul 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martin Piest, Johan F J Engbersen
May 25, 2011·Nature Reviews. Cancer·William R Wilson, Michael P Hay
Sep 21, 2012·Journal of the American Chemical Society·Jennifer S ButlerPeter J Sadler
Dec 7, 2013·Chemical Society Reviews·Subramani SwaminathanFrançisco M Raymo
Jul 16, 2014·Nature Reviews. Genetics·Hao YinDaniel G Anderson
Jul 30, 2015·Biomaterials Science·Zhe YangXintao Shuai
Nov 4, 2015·Advanced Drug Delivery Reviews·Pei Yun TeoYi Yan Yang
Mar 8, 2016·Advanced Materials·Chenggen QianZhen Gu
May 2, 2017·Journal of the American Chemical Society·Hyo Sung JungJong Seung Kim
Aug 6, 2017·Advanced Drug Delivery Reviews·Zhuxian ZhouYouqing Shen
Nov 4, 2017·Cell Death and Differentiation·Joseph T Opferman, Anisha Kothari
Nov 7, 2017·Biomaterials Science·Weitong SunXintao Shuai
Feb 7, 2018·Advances in Cancer Research·Santanu MajiRupesh Dash
Dec 26, 2018·ACS Applied Materials & Interfaces·Junxia WangXianzhu Yang
Feb 12, 2019·Journal of the American Chemical Society·Jingchao LiKanyi Pu
Apr 24, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Kezi YaoNicola J Farrer
May 29, 2019·Accounts of Chemical Research·Richard A ReviaMiqin Zhang
Jan 1, 2018·Cell Death and Differentiation·Joseph T Opferman, Anisha Kothari

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Methods Mentioned

BETA
protein assay
X-ray
dynamic light scattering
nanoprecipitation

Software Mentioned

EL

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