Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light.

Nature Communications
Gi Byoung HwangIvan P Parkin

Abstract

The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light source or UV-activation is usually required. Here we report a photobactericidal polymer containing crystal violet (CV) and thiolated gold nanocluster ([Au25(Cys)18]) activated at a low flux levels of white light. It was shown that the polymer encapsulated with CV do not have photobactericidal activity under white light illumination of an average 312 lux. However, encapsulation of [Au25(Cys)18] and CV into the polymer activates potent photobactericidal activity. The study of the photobactericidal mechanism shows that additional encapsulation of [Au25(Cys)18] into the CV treated polymer promotes redox reactions through generation of alternative electron transfer pathways, while it reduces photochemical reaction type-ІІ pathways resulting in promotion of hydrogen peroxide (H2O2) production.

References

Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·M Wainwright
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael R Hamblin, Tayyaba Hasan
Feb 9, 2006·The Journal of Antimicrobial Chemotherapy·Simon WoodColin Robinson
Aug 18, 2006·BMC Infectious Diseases·Axel KramerGünter Kampf
Jan 9, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mary K HaydenRobert A Weinstein
Apr 15, 2008·Journal of the American Chemical Society·Manzhou ZhuRongchao Jin
Sep 16, 2008·Analytica Chimica Acta·Bernd O KellerRandy M Whittal
Jun 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kirk HuslageDavid J Weber
Jun 15, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Farrin A ManianMichelle Wiechens
Oct 20, 2015·ACS Applied Materials & Interfaces·Gi Byoung HwangIvan P Parkin
Jun 7, 2017·Chemical Reviews·Indranath Chakraborty, Thalappil Pradeep
Jun 9, 2017·ACS Nano·Kaiyuan ZhengJianping Xie
Sep 22, 2017·The Journal of Physical Chemistry Letters·Kyuju KwakGuda Ramakrishna
Feb 1, 2018·Scientific Reports·Vijay KrishnaBrij Moudgil
Sep 5, 2018·Nature Microbiology·Jean Y H LeeBenjamin P Howden
Sep 13, 2018·Advanced Materials·Guozhen ZhangYi Luo
Feb 10, 2019·Nature Reviews. Microbiology·Nicholas A TurnerVance G Fowler
Aug 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sandeep K SehmiIvan P Parkin
Mar 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gi Byoung HwangIvan P Parkin

❮ Previous
Next ❯

Citations

Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan LiVincent M Rotello
Apr 8, 2021·Nature Communications·Shoupeng CaoJan C M van Hest
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mya Mya KhinXiao Hu
Jun 25, 2021·Nature Communications·Z L ShawSumeet Walia
Oct 20, 2020·ACS Applied Materials & Interfaces·Gi Byoung HwangIvan P Parkin

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
transmission electron microscopy
fluorescence microscopy

Software Mentioned

Excel
FluoFit
ImageJ
PicoQuant Fluofit

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.