Photobiomodulation and Cancer: What Is the Truth?

Photomedicine and Laser Surgery
Michael R HamblinJustin R Strahan

Abstract

Photobiomodulation (PBM) therapy is a rapidly growing approach to stimulate healing, reduce pain, increase athletic performance, and improve general wellness. Applying PBM therapy over the site of a tumor has been considered to be a contraindication. However, since another growing use of PBM therapy is to mitigate the side effects of cancer therapy, this short review seeks to critically examine the evidence of whether PBM therapy is beneficial or harmful in cancer patients. PubMed and Google Scholar were searched. Although there are a few articles suggesting that PBM therapy can be detrimental in animal models of tumors, there are also many articles that suggest the opposite and that light can directly damage the tumor, can potentiate other cancer therapies, and can stimulate the host immune system. Moreover, there are two clinical trials showing increased survival in cancer patients who received PBM therapy. PBM therapy may have benefits in cancer patients and should be further investigated.

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Citations

Jun 15, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Felipe Martins SilveiraManoela Domingues Martins
May 29, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Joy LodewijckxJeroen Mebis
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Oct 27, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Lucas Augusto da Silva, Sérgio Luiz Pinheiro
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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
irradiate

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