Photobiomodulation and different macrophages phenotypes during muscle tissue repair

Journal of Cellular and Molecular Medicine
Nadhia Helena Costa SouzaKristianne Porta Santos Fernandes

Abstract

Macrophages play a very important role in the conduction of several regenerative processes mainly due to their plasticity and multiple functions. In the muscle repair process, while M1 macrophages regulate the inflammatory and proliferative phases, M2 (anti-inflammatory) macrophages direct the differentiation and remodelling phases, leading to tissue regeneration. The aim of this study was to evaluate the effect of red and near infrared (NIR) photobiomodulation (PBM) on macrophage phenotypes and correlate these findings with the repair process following acute muscle injury. Wistar rats were divided into 4 groups: control; muscle injury; muscle injury + red PBM; and muscle injury + NIR PBM. After 2, 4 and 7 days, the tibialis anterior muscle was processed for analysis. Macrophages phenotypic profile was evaluated by immunohistochemistry and correlated with the different stages of the skeletal muscle repair by the qualitative and quantitative morphological analysis as well as by the evaluation of IL-6, TNF-α and TGF-β mRNA expression. Photobiomodulation at both wavelengths was able to decrease the number of CD68+ (M1) macrophages 2 days after muscle injury and increase the number of CD163+ (M2) macrophages 7 days after injury. Ho...Continue Reading

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Citations

Jan 8, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Efthymios ParonisAndreas Lazaris
Jan 19, 2020·Annals of Hematology·Jian-Xin SongYa-Lian Sa
Aug 1, 2020·Frontiers in Pharmacology·Yi LiPeifu Tang
Aug 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven S WelcJames G Tidball
Mar 21, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Evaldo Moreira da SilvaKristianne Porta Santos Fernandes
Oct 14, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Camilla Garcia OliveiraMarucia Chacur
Feb 28, 2021·Journal of Biophotonics·Kaline de Brito SousaKristianne Porta Santos Fernandes
Oct 30, 2019·ACS Applied Materials & Interfaces·Xiaowen ZhengChangyou Gao
Jan 4, 2022·Journal of Biophotonics·Talita Christine Camillo LopezKristianne Porta Santos Fernandes

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Datasets Mentioned

BETA
NM021578.2

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GraphPad Prism
Image J cell count

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