Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions

Molecular Neurobiology
Ruimin WangQuanguang Zhang

Abstract

Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM involves the use of low-level laser light therapy to influence cell behavior. In this study, we evaluated the therapeutic effects of PBM treatment with an 808-nm diode laser initiated 6 h after GCI. It was noted that PBM dose-dependently protected against GCI-induced neuronal death in the vulnerable hippocampal CA1 subregion. Functional assessments demonstrated that PBM markedly preserved both short-term (a week) and long-term (6 months) spatial learning and memory function following GCI. Further mechanistic studies revealed that PBM post-treatment (a) preserved healthy mitochondrial dynamics and suppressed substantial mitochondrial fragmentation of CA1 neurons, by reducing the detrimental Drp1 GTPase activity and its interactions with adaptor proteins Mff and Fis1 and by balancing mitochondrial targeting fission and fusion protein levels; (b) reduced mitochondrial oxidative damage and excessive mitophagy and restored mitochondrial overall hea...Continue Reading

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Citations

Oct 28, 2019·Journal of Biophotonics·Baocheng YangXianliang Yan
Sep 4, 2020·Medical Acupuncture·Gerhard Litscher
Jun 2, 2020·Translational Neurodegeneration·Luodan YangQuanguang Zhang
Dec 4, 2020·Neural Regeneration Research·Muyue YangZhihui Sun
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Apr 7, 2021·Cellular and Molecular Life Sciences : CMLS·Rachel JamesThomas H Gillingwater
May 1, 2021·International Journal of Molecular Sciences·Silvia RaveraAndrea Amaroli
May 7, 2021·Medicinal Research Reviews·Qing-Zhang TuoPeng Lei
Jul 19, 2021·Molecular Neurobiology·Mimi WuZhengliang Ma
Jul 29, 2021·Molecular Neurobiology·Elisabetta GeraceGuido Mannaioni

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Methods Mentioned

BETA
GTPase
Protein Assay
immunoprecipitation
electrophoresis
proximity ligation assay
Assay
protease assay
Confocal microscopy
co-IP
electron microscopy

Software Mentioned

Systat
ImageJ
ANY
maze
SigmaStat
PhotoThera
NIH
NIH ImageJ

Related Concepts

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Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

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brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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