Photobiomodulation Therapy Attenuates Hypoxic-Ischemic Injury in a Neonatal Rat Model

Journal of Molecular Neuroscience : MN
Lorelei Donovan TuckerQuan-Guang Zhang

Abstract

Photobiomodulation (PBM) has been demonstrated as a neuroprotective strategy, but its effect on perinatal hypoxic-ischemic encephalopathy is still unknown. The current study was designed to shed light on the potential beneficial effect of PBM on neonatal brain injury induced by hypoxia ischemia (HI) in a rat model. Postnatal rats were subjected to hypoxic-ischemic insult, followed by a 7-day PBM treatment via a continuous wave diode laser with a wavelength of 808 nm. We demonstrated that PBM treatment significantly reduced HI-induced brain lesion in both the cortex and hippocampal CA1 subregions. Molecular studies indicated that PBM treatment profoundly restored mitochondrial dynamics by suppressing HI-induced mitochondrial fragmentation. Further investigation of mitochondrial function revealed that PBM treatment remarkably attenuated mitochondrial membrane collapse, accompanied with enhanced ATP synthesis in neonatal HI rats. In addition, PBM treatment led to robust inhibition of oxidative damage, manifested by significant reduction in the productions of 4-HNE, P-H2AX (S139), malondialdehyde (MDA), as well as protein carbonyls. Finally, PBM treatment suppressed the activation of mitochondria-dependent neuronal apoptosis in HI ...Continue Reading

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Citations

Oct 28, 2019·Journal of Biophotonics·Baocheng YangXianliang Yan
Jun 2, 2020·Translational Neurodegeneration·Luodan YangQuanguang Zhang
Mar 8, 2019·International Journal of Molecular Sciences·Kyuchang KimSehwan Shim
Jun 4, 2019·Lasers in Medical Science·Priscila Thaís Rodrigues de AbreuTarcília Aparecida Silva
Dec 4, 2020·Neural Regeneration Research·Muyue YangZhihui Sun
Jan 17, 2020·The American Journal of Pathology·Jinghua BuWei Li
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Luodan YangQuanguang Zhang
Jul 29, 2021·Molecular Neurobiology·Elisabetta GeraceGuido Mannaioni

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Methods Mentioned

BETA
light microscopy
Protein Assay
confocal microscopy

Software Mentioned

PBM
Image J
ImageJ
SigmaStat

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