Photocarcinogenicity of 8-methoxypsoralen and aflatoxin B1 with longwave ultraviolet light

Cancer Letters
K NagayoP S Song

Abstract

The carcinogenicity of 8-methoxypsoralen (8-MOP) and aflatoxin B1 (AFB1) with longwave ultraviolet light (UVA) to hairless mouse skin was investigated. Skin tumors were induced efficiently by 8-MOP + UVA, and the time to 50% tumor incidence was about 24 weeks. Histopathologically, some tumors were squamous cell carcinomas. AFB1 did not show any phototoxic and photocarcinogenic effects on mouse skin in this study. Although the structure and the photoreactivity of AFB1 to DNA were similar to those of 8-MOP, the photocarcinogenic response of these compounds to mouse skin was quite different.

References

Jun 1, 1979·Photochemistry and Photobiology·P S Song, K J Tapley
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee
Dec 1, 1972·Canadian Journal of Microbiology·R C Smith, W C Neely
Nov 1, 1971·Photochemistry and Photobiology·E Cavalieri, M Calvin
Oct 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·W Lijinsky, W H Butler

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