Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines

Organic Letters
Qiang WeiWen-Jing Xiao

Abstract

A general visible light induced photoredox-catalyzed radical trifluoromethylation/cyclization cascade of β-aryl-β,γ-unsaturated hydrazones and oximes is described. The protocol enables an efficient access to various densely functionalized and biologically important CF3-containing dihydropyrazoles and isoxazolines with generally high yields.

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Citations

Jan 12, 2016·Organic Letters·Mingyang FuZhigang Yang
Jul 15, 2016·Journal of the American Chemical Society·Jin-Shun LinXin-Yuan Liu
Jan 6, 2017·The Journal of Organic Chemistry·Zhong-Quan Liu, Dong Liu
Mar 8, 2016·Chemistry : a European Journal·Shi-Meng WangCheng-Pan Zhang
Jun 24, 2017·Chemical Communications : Chem Comm·Huanfeng JiangWanqing Wu
Nov 8, 2016·Chemical Society Reviews·Nathaniel CorriganCyrille Boyer
Nov 3, 2016·Chemical Communications : Chem Comm·Florian PünnerMikiko Sodeoka
Jun 7, 2018·Organic & Biomolecular Chemistry·Satoko TsujibayashiHiroshi Matsubara
Feb 16, 2019·Organic & Biomolecular Chemistry·Yanling JiWei Huang
Apr 27, 2019·Chemistry : a European Journal·Qiang WangQingmin Wang
Jul 10, 2019·Chemical Communications : Chem Comm·Xiaobing LiuQiuling Song
Sep 19, 2019·Chemical Communications : Chem Comm·Yong-Hong LiShang-Dong Yang
Jun 12, 2020·Organic & Biomolecular Chemistry·Jianhua LiaoRenshi Luo

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