Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells

Angewandte Chemie
Jia-Quan XuWei-Hua Huang

Abstract

Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO2 to form a sandwiching RGO@TiO2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs-RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.

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Citations

Mar 19, 2016·Analytical Chemistry·Changliang ZhangGuo-Jun Zhang
Nov 22, 2017·Nanomaterials·Lili YangNguyen Viet Long
Dec 29, 2017·Analytical Chemistry·Nan ZhangHong-Yuan Chen
Nov 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rong WuJun-Jie Zhu

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