Photochemical hammerhead ribozyme activation

Bioorganic & Medicinal Chemistry Letters
Douglas D Young, Alexander Deiters

Abstract

We report the light-activation of allosteric cis and trans acting ribozymes via decaging of a small organic molecule ligand. To achieve this effectively, we introduce an optimized N-caging group based on a nitrobenzyl core structure. This approach can potentially be employed toward a light-induced control of gene function.

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Citations

Sep 1, 2009·Cellular and Molecular Life Sciences : CMLS·Cedric ReymondJean-Pierre Perreault
Aug 29, 2013·Accounts of Chemical Research·Qingyang Liu, Alexander Deiters
May 22, 2008·Molecular BioSystems·Hrvoje LusicAlexander Deiters
Sep 28, 2010·Chemical Communications : Chem Comm·Alexander NierthAndres Jäschke
Jan 18, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alexander G RussellJohn S Snaith
Apr 2, 2008·Zebrafish·Alexander Deiters, Jeffrey A Yoder
Sep 25, 2012·Nucleic Acids Research·Yuan WangXinjing Tang
Jul 10, 2007·Journal of Molecular Biology·Hyun-Wu LeeDipankar Sen
Jan 12, 2008·Chemical Communications : Chem Comm·Douglas D YoungAlexander Deiters
May 31, 2018·Chemical Communications : Chem Comm·V DhamodharanYohei Yokobayashi
Aug 15, 2012·Angewandte Chemie·Thomas PauloehrlChristopher Barner-Kowollik
May 28, 2014·Chembiochem : a European Journal of Chemical Biology·Steven WalshGavin J Williams
Sep 4, 2015·Angewandte Chemie·Guillaume DelaittreChristopher Barner-Kowollik
Apr 12, 2008·Chembiochem : a European Journal of Chemical Biology·Douglas D Young, Alexander Deiters
Jan 25, 2007·Molecular BioSystems·XinJing Tang, Ivan J Dmochowski
Mar 23, 2007·Organic & Biomolecular Chemistry·Douglas D Young, Alexander Deiters
Oct 19, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bernhard WulffenAlexander Heckel
Dec 18, 2015·Chembiochem : a European Journal of Chemical Biology·Dennis BinderThomas Drepper
Jul 26, 2012·Angewandte Chemie·Clara BriekeAlexander Heckel
Oct 14, 2011·Organic & Biomolecular Chemistry·Wesleigh E Georgianna, Douglas D Young
May 28, 2021·RSC Chemical Biology·Amirrasoul TavakoliJung-Hyun Min
Jun 8, 2021·Chemical Science·Ilse M WellemanWiktor Szymański
Jul 15, 2021·Advanced Science·Shasha LuXiurong Yang
Jul 31, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Adam M KabzaJonathan T Sczepanski
Sep 1, 2020·Journal of the American Chemical Society·Lu XiaoEric T Kool
Sep 11, 2021·Nature Chemical Biology·Anne M van der LeunTon N Schumacher

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