Photochemical Transformation of Aminoglycoside Antibiotics in Simulated Natural Waters

Environmental Science & Technology
Rui LiWeihua Song

Abstract

Aminoglycoside antibiotics are widely used in human therapy and veterinary medicine. We report herein a detailed study on the natural-organic-matter- (NOM-) photosensitized degradation of aminoglycosides in aqueous media under simulated solar irradiation. It appears that the direct reaction of the excited states of NOM ((3)NOM*) with aminoglycosides is minor. The contributions of reactive oxygen species (ROSs) in the bulk solutions are also unimportant, as determined by an assessment based on steady-state concentrations and bimolecular reaction rate constants in a homogeneous reaction model. The inhibition of the photodegradation by isopropamide is rationalized through competitive sorption with aminoglycosides on the NOM surface, whereas the addition of isopropanol negligibly affects degradation because it quenches HO(•) in the bulk solution but not HO(•) localized on the NOM surface where aminoglycosides reside. Therefore, a sorption-enhanced phototransformation mechanism is proposed. The sorption of aminoglycosides on NOM follows a dual-mode model involving Langmuir and linear isotherms. The steady-state concentration of HO(•) on the surface of NOM was calculated as 10(-14) M, 2 orders of magnitude higher than that in the bul...Continue Reading

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Citations

Nov 2, 2016·Environmental Science & Technology·Lijuan YinWeihua Song
Jan 27, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·UNKNOWN United Nations Environment Programme, Environmental Effects Assessment Panel
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Aug 30, 2018·Environmental Science and Pollution Research International·Xiuyi HuaZhiyong Guo
Jul 8, 2019·Environmental Science and Pollution Research International·Jun LuChengzhu Zhu
Apr 22, 2017·Environmental Science and Pollution Research International·Yanru ShenJunxian Shi
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Jul 22, 2021·Environmental Science & Technology·Shuwen YanWeihua Song
Nov 9, 2021·Environmental Science & Technology·Shuangshuang ChengXin Yang

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Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.