Photochemically Controlled Drug Dosing from a Polymeric Scaffold

Pharmaceutical Research
Louise DonnellyColin P McCoy

Abstract

To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold. Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation. Photo-liberation of drug from pMEA into phosphate buffered saline was monitored using UV-vis spectroscopy. The synthetic procedures yielded the desired drug conjugates with full supporting characterisation. Drug regeneration through photolysis of the synthesised conjugates was successful in both acetonitrile solution and within the pMEA scaffold upon UV irradiation. Conjugates were retained within the pMEA scaffold with exclusive drug liberation following irradiation and increased drug dose with increasing exposure. Multi-dosing capacity was demonstrated though the ability of successive irradiation periods to generate further bursts of drug. This study demonstrates the first application of photochemically co...Continue Reading

References

Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Jan 5, 2002·Advanced Drug Delivery Reviews·Takashi MiyataKatsuhiko Nakamae
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Dec 1, 2010·Journal of Biological Engineering·Jin-Oh YouDebra T Auguste

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Citations

Aug 29, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bhavya KhuranaMathias O Senge
Jan 4, 2020·Photodiagnosis and Photodynamic Therapy·Liberty N GendronJennifer R Shell

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Methods Mentioned

BETA
acylation
NMR

Software Mentioned

UV WinLab

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