Photochemically induced focal cochlear lesions in the guinea pig: II. A transmission electron microscope study

Microscopy Research and Technique
H MiyashitaT Hoshino

Abstract

Photochemically induced focal lesions in guinea pig cochleas were studied by light microscopy and transmission electron microscopy. The lesions were induced in the second cochlear turns of 35 adult guinea pigs by illumination for 10 minutes with a focused green light immediately after a rose bengal solution was injected into the jugular vein. The cochlear lateral wall and organ of Corti were examined 5, 10, 20, 30, and 90 minutes, 12 and 24 hours, and 3, 7, and 30 days after the procedure. Aggregations of platelets and red blood cells were found in strial capillaries at 5 minutes after illumination. After 30 minutes, marginal cell surfaces protruded into the endolymphatic space; surface membranes were ruptured and the cytoplasm was expelled into the space. In outer hair cells, disruption of the cellular membrane was found near the cuticular plate 12 hours after the procedure. All cellular elements of the lateral wall and organ of Corti were markedly degenerated in the 30-day specimens. Histological changes found in the stria vascularis were consistent with cell damage caused by active oxygen species. It is likely that the stria vascularis is more sensitive to the photochemical reaction than other parts of the cochlea. Cell dama...Continue Reading

References

Jan 1, 1987·Acta Neuropathologica·W D DietrichJ R Bethea
May 1, 1985·Annals of Neurology·B D WatsonM D Ginsberg
Jun 1, 1956·The Annals of Otology, Rhinology, and Laryngology·R KIMURA, H B PERLMAN
Mar 1, 1958·The Annals of Otology, Rhinology, and Laryngology·R KIMURA, H B PERLMAN

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Citations

Mar 28, 2001·The Annals of Otology, Rhinology, and Laryngology·R Wu, T Hoshino

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