Photochemotherapy beyond psoriasis
Photochemotherapy involves the therapeutic use of nonionizing radiation in combination with a photosensitizing chemical to trigger a photochemical reaction that mediates a beneficial effect. The successful introduction and widespread use of psoralen photochemotherapy (PUVA) in the management of psoriasis was the chief stimulus for recent interest in the therapeutic use of nonionizing radiation in various other dermatoses. This article discusses the expanding spectrum of diseases responding to PUVA therapy. More than 30 conditions such as atopic dermatitis, mycosis fungoides, vitiligo, the photodermatoses, chronic graft-versus-host disease, and granuloma annulare have been successfully treated with oral psoralen photochemotherapy. Various mechanisms of response to treatment are discussed including photoimmunologic effects, selective cytotoxicity, alterations of cell function, and stimulation of melanocytes. Finally, the limitations to the use of PUVA therapy are identified and its future use in other cutaneous and systemic diseases are discussed.
Oral photochemotherapy in the treatment of lichen planus (LP). Clinical results, histological and ultrastructural observations
Effects of 8-methoxypsoralen-induced phototoxic effects on mammalian epidermal macromolecule synthesis in vivo
A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in the initial treatment of mycosis fungoides
The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents
UVB phototherapy and photochemotherapy (PUVA) in the treatment of polymorphic light eruption and solar urticaria
Photochemotherapy in cutaneous T cell lymphoma and parapsoriasis en plaques. Long-term follow-up in forty-three patients
Methoxsalen and ultraviolet A radiation in treatment of chronic cutaneous graft-versus-host reaction
Inhibition of delayed hypersensitivity reaction in skin (DNCB test) by 8-methoxypsoralen photochemotherapy. Possible basis for pseudo-promoting action in skin carcinogenesis?
Suppression of palmoplantar pustulosis symptoms with oral 8-methoxypsoralen and high-intensity UVA irradiation
Treatment of parapsoriasis and mycosis fungoides: the role of psoralen and long-wave ultraviolet light A (PUVA)
Histological changes observed in the skin of patients with mycosis fungoides receiving photochemotherapy
Sensitivity of mononuclear cells to PUVA: effect on subsequent stimulation with mitogens and on exclusion of trypan blue dye
Oral psoralen photochemotherapy (PUVA) for pruritus associated with polycythemia vera and myelofibrosis
Complete remissions in psoralen and UV-A (PUVA)-refractory mycosis fungoides-type cutaneous T-cell lymphoma with combined interferon alfa and PUVA
Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin
Laser resurfacing-induced hypopigmentation: histologic alterations and repigmentation with topical photochemotherapy
Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation
The role of phototherapy in cutaneous chronic graft-vs-host disease: a retrospective study and review of the literature
Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research
Limited Capacity or Involvement of Excision Repair, Double-Strand Breaks, or Translesion Synthesis for Psoralen Cross-Link Repair in Escherichia coli
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer
Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.
Blood And Marrow Transplantation
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.