Photocontact allergic and phototoxic studies of chlorproethazine

Photodermatology, Photoimmunology & Photomedicine
Alastair KerrJames Ferguson

Abstract

Neuriplege cream was available as a non-prescription medication in France until its withdrawal from the market by regulatory authorities in January 2007. Its active ingredient is the phenothiazine chlorproethazine (CPE). Before its withdrawal, we investigated the photocontact allergic and phototoxic potential of Neuriplege cream and CPE. An in vitro phototoxic study was performed in HaCaT keratinocytes using the neutral red dye phototoxic assay. Phototoxicity and photocontact allergy were assessed in humans by photopatch testing. In vitro, a 1 h incubation of keratinocytes with CPE was approximately 13 times as toxic to the cells in the presence of ultraviolet light compared with incubation with the drug alone. Of two healthy volunteers initially photopatch tested to Neuriplege cream on the arm, one developed a phototoxic reaction. These two volunteers were then photopatch tested to Neuriplege and CPE on the back with seven additional healthy volunteers. Both of the initial study volunteers experienced a photocontact allergic reaction to Neuriplege as is upon this re-exposure. Of the seven volunteers not previously exposed to Neuriplege as is, five developed phototoxic reactions. This study demonstrates the strong phototoxic an...Continue Reading

References

Apr 1, 1992·Contact Dermatitis·C LoescheP Thomas
Jan 22, 2000·Journal of the American Academy of Dermatology·N J NeumannP Lehmann
Apr 25, 2000·The British Journal of Dermatology·H K Bell, L E Rhodes
May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N J TraynorN K Gibbs

❮ Previous
Next ❯

Citations

Aug 6, 2013·Journal of Photochemistry and Photobiology. B, Biology·Gemma A BarronJulie A Woods
Jun 6, 2009·Contact Dermatitis·José Carlos CardosoAmérico Figueiredo
Apr 27, 2010·Photodermatology, Photoimmunology & Photomedicine·Alastair Kerr, James Ferguson
Oct 5, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sally Ibbotson
Jan 11, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Lujuan GaoXia Dou
Oct 3, 2014·Reviews on Environmental Health·Golara Honari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of the European Academy of Dermatology and Venereology : JEADV
D P BruynzeelEuropean Taskforce for Photopatch Testing
Proceedings of the National Academy of Sciences of the United States of America
L A DoyleDouglas D Ross
© 2021 Meta ULC. All rights reserved