Photocontrollable NO-releasing compounds and their biological applications

Journal of Clinical Biochemistry and Nutrition
Hidehiko Nakagawa

Abstract

Photocontrollable nitric oxide (NO)-releasing compounds, or caged NOs, are very useful to expose cells or tissues to NO in a spatiotemporally well-controlled manner, e.g., for precise investigations of biological responses to NO and NO-related signaling pathways. We have developed photocontrollable NO releasers based on two mechanisms: photoinduced isomerization reaction of a dimethylnitrobenzene moiety conjugated with a pi-electron system, and photoinduced electron transfer of a moderately electron-rich N-nitroso aminophenol moiety linked with an antenna dye moiety. In this review, we describe the development of our photoinduced NO releasers based on these mechanisms, and present examples of cellular and ex vivo applications.

References

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Aug 18, 2005·Journal of the American Chemical Society·Takayoshi SuzukiNaoki Miyata
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May 15, 2009·Journal of the American Chemical Society·Kazuhiro HishikawaNaoki Miyata
Apr 16, 2014·Journal of the American Chemical Society·Naoya IedaHidehiko Nakagawa
Dec 4, 2014·Bioorganic & Medicinal Chemistry Letters·Kai KitamuraHidehiko Nakagawa
Jun 16, 2015·Bioorganic & Medicinal Chemistry Letters·Naoya IedaHidehiko Nakagawa

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Citations

Sep 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mimimorena SeggioSalvatore Sortino
Nov 8, 2020·Journal of Fluorescence·Tatyana Yu DranovaAlexander E Moskalensky

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