Photocrosslinkable hyaluronic acid as an internal wetting agent in model conventional and silicone hydrogel contact lenses

Journal of Biomedical Materials Research. Part a
Andrea WeeksHeather Sheardown

Abstract

Photocrosslinkable methacrylated hyaluronic acid (HA) was prepared and incorporated into model conventional and silicone hydrogel contact lenses as an internal wetting agent. The molecular weight of the HA, the degree of methacrylation as well as the amount (0.25 to 1.0 wt %) incorporated were varied. The HA-containing hydrogels were analyzed using a variety of techniques including water contact angles, equilibrium water content (EWC), and lysozyme sorption. The presence of HA could be detected in the materials using X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy-attenuated total reflectance. The materials containing methacrylated HA had improved hydrophilicity and reduced lysozyme sorption. Effects of modified HA on EWC were dependent upon the materials but generally increased water uptake. Increased mobility of the HA associated with a lower molecular weight and lower degree of methacrylation was found to be more effective in improving hydrophilicity and decreasing lysozyme sorption than the less mobile HA. All results found suggest that photocrosslinkable HA has significant potential in contact lens applications.

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Citations

Sep 17, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Robin Chalmers
Sep 4, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Charles J WhiteMark E Byrne
Sep 10, 2016·Current Eye Research·Sebastian StachStefano Giovanzana
Sep 16, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael SamsomTannin A Schmidt
Dec 17, 2014·Journal of Biomedical Materials Research. Part a·Stefan M PatersonHeather Sheardown
Jan 19, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Frances Lasowski, Heather Sheardown
Apr 19, 2015·Journal of Biomaterials Applications·Myrto KorogiannakiHeather Sheardown
Jul 9, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael SamsomTannin A Schmidt
Jun 9, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Katsuhide YamasakiLyndon Jones
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Mark WillcoxLyndon Jones
Dec 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Myrto KorogiannakiHeather Sheardown

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