Photocurable Hyperbranched Polymer Medical Glue for Water-Resistant Bonding.

Biomacromolecules
Yifan ZhangXiaoya Liu

Abstract

Medical glue represents a suitable tool to stop wound bleeding, seal wounds, bond tissues, or implant materials. However, the development of a medical glue for durable underwater bonding remains a challenge. Herein, we developed a hydrophobic hyperbranched polymer-based medical glue with water-resistant bonding ability. Specifically, the hyperbranched polythioether (HBPTE) with abundant terminal thiol groups was first prepared through a simple one-pot thiol-Michael polyaddition reaction. Due to the hyperbranched molecular structure, HBPTE is a liquid material under room temperature, thus enabling the manufacturing of a photocurable HBPTE glue by the direct addition of poly(ethylene glycol) dimethacrylate and a photoinitiator without introduction of a solvent. This solventless HBPTE glue exhibited a maximum underwater adhesive strength of 36 kPa on porcine skin compared to only <10 kPa of the commercial fibrin glue and cyanoacrylate glue. Moreover, since the hydrophobic cross-linked network resists penetration of water, the HBPTE glue minimally swelled (2-10%) and could maintain a glass sheet structure bonded together even after 2 weeks underwater. Furthermore, an in vitro cytotoxicity test showed that the HBPTE glue did not lea...Continue Reading

References

Aug 28, 1998·Biomaterials·S Venkatraman, R Gale
Jul 9, 1999·Journal of Biomedical Materials Research·S L Goodman
Dec 18, 2001·Journal of Biomedical Materials Research·David H SierraJack E Lemons
Aug 9, 2006·International Journal of Biological Macromolecules·P FerreiraM H Gil
Nov 28, 2006·Journal of Biomechanics·H SarafJ C Roberts
Jun 26, 2007·Journal of Materials Science. Materials in Medicine·P FerreiraM H Gil
Apr 9, 2008·Current Topics in Medicinal Chemistry·Paul ThevenotLiping Tang
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver
May 2, 2009·The Urologic Clinics of North America·Jeffery C Wheat, J Stuart Wolf
Mar 18, 2011·ACS Applied Materials & Interfaces·Sarbjit KaurRussell J Stewart
May 15, 2013·Advanced Functional Materials·Boaz MizrahiDaniel S Kohane
Jul 16, 2013·Journal of Biomaterials Science. Polymer Edition·Victoria LeszczakKetul C Popat
Jan 10, 2014·Science Translational Medicine·Nora LangPedro J del Nido
Mar 29, 2014·Annals of Surgery·Konstantinos Aristotelis VakalopoulosJohan Frederik Lange
Jan 1, 2015·International Journal of Molecular Sciences·Joanna RydzDarinka Christova
Feb 5, 2015·Chemical Society Reviews·C Ghobril, M W Grinstaff
Apr 24, 2015·Chemical Society Reviews·Yaochen ZhengChao Gao
Jan 27, 2017·Biomacromolecules·Richard D O'RorkeTerry W J Steele
Jan 31, 2017·Acta Biomaterialia·Biji BalakrishnanAthipettah Jayakrishnan
Jul 29, 2017·Science·J LiD J Mooney
Sep 2, 2017·Biomacromolecules·Vrushali Bhagat, Matthew L Becker
Feb 10, 2018·Biomacromolecules·Himansu Sekhar NandaTerry W J Steele
Feb 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cormac DuffyFawaz Aldabbagh
Apr 24, 2018·Acta Biomaterialia·Wenzhen ZhuDong-An Wang
Jun 6, 2018·Macromolecular Rapid Communications·Cansu AydoganYusuf Yagci
Jul 1, 2019·International Journal of Biological Macromolecules·Ritu Jain, Sarika Wairkar
Nov 2, 2019·Nature·Hyunwoo YukXuanhe Zhao

❮ Previous
Next ❯

Citations

Apr 27, 2021·Biomedical Materials·Biji BalakrishnanAthipettah Jayakrishnan
Jun 25, 2021·ACS Biomaterials Science & Engineering·Yifan ZhangXiaoya Liu
Jul 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan ZhangXiaoya Liu
Sep 18, 2021·Advanced Materials·Hailong Fan, Jian Ping Gong
Oct 16, 2021·ACS Applied Materials & Interfaces·Yongsen ZhouZuankai Wang
Nov 10, 2021·Chemical Society Reviews·Amal NarayananAbraham Joy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nursing Research
F S Downs
Health Data Management
Howard J Anderson
Plastic and Reconstructive Surgery
S Baxt
The Journal of Thoracic and Cardiovascular Surgery
Francois Dagenais
Polski tygodnik lekarski
W Janicki
© 2021 Meta ULC. All rights reserved