Photodynamic action of rose bengal on isolated rat pancreatic acini: stimulation of amylase release.

FEBS Letters
E K Matthews, Z J Cui

Abstract

The halogenated fluorescein derivative, rose bengal, upon photon activation, elicits amylase secretion from isolated, perifused pancreatic acini. This effect is due to production of highly reactive singlet delta oxygen which can permeabilize the cell membrane and may also react chemically with secretagogue receptors, or other functional components of the membrane such as the G-proteins. The profile of photodynamically induced amylase secretion is anion-dependent: it becomes biphasic when the chloride ion is substituted by the glutamate ion, an effect attributed to the action of glutamate on the ionic transport systems of the zymogen granule membrane.

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Citations

Apr 20, 2017·Frontiers in Physiology·Hong Ning JiangZong Jie Cui
Feb 23, 2020·PloS One·Alexander D FinoshinYulia V Lyupina
Oct 16, 2002·World Journal of Gastroenterology : WJG·Zong-Jie Cui, Xue-Hui He
Jun 6, 2018·Cellular and Molecular Neurobiology·Wen Yi JiangZong Jie Cui
Nov 14, 1997·The Journal of Physiology·Z J Cui, T Kanno
Jul 21, 1999·Journal of Biomechanical Engineering·N A BuschM L Yarmush
Jan 1, 1995·Lasers in Surgery and Medicine·K T MoestaT S Mang

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