Photodynamic Activities of Porphyrin Derivative-Cyclodextrin Complexes by Photoirradiation

ACS Medicinal Chemistry Letters
Atsushi IkedaAkio Kuroda

Abstract

Water-soluble cyclodextrin (CyD) complexed with porphyrin derivatives with different substituents in the meso-positions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step toward the optimization of porphyrin derivatives as photosensitizers.

References

Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Dec 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S Goldstein, G Czapski
Jul 1, 1994·Applied Microbiology and Biotechnology·R Bar, S Ulitzur
Aug 15, 2002·Journal of the American Chemical Society·Koji KanoYasuhisa Kuroda
Apr 5, 2007·Organic & Biomolecular Chemistry·Atsushi IkedaTatsuo Takeya
Oct 22, 2008·Advanced Drug Delivery Reviews·Dev Kumar ChatterjeeYong Zhang
Aug 15, 2009·Journal of Photochemistry and Photobiology. B, Biology·Shiho HiroharaShigenobu Yano
Dec 20, 2011·Chemistry : a European Journal·Youichi TsuchiyaSeiji Shinkai

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Citations

Aug 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amina Ben MihoubSamir Acherar
Nov 27, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Toshimi NakayaAtsushi Ikeda
Mar 7, 2019·Organic & Biomolecular Chemistry·Shuhei SatakeAtsushi Ikeda
Nov 26, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Shodai HinoAtsushi Ikeda
Jul 22, 2018·Current Medicinal Chemistry·Antonio FranconettiJosé G Fernandez-Bolanos
Sep 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoxiao ShiZhigang Xu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilche GjuroskiMartina Vermathen
Dec 7, 2019·Journal of Medicinal Chemistry·Irene M Mavridis, Konstantina Yannakopoulou
Dec 6, 2021·Photochemistry and Photobiology·Rukayat S Bojesomo, Na'il Saleh

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