Photodynamic Anticancer Activities of Multifunctional Cobalt Ferrite Nanoparticles in Various Cancer Cells

Journal of Biomedical Nanotechnology
Bong Joo ParkEun Ha Choi

Abstract

To develop novel multifunctional magnetic nanoparticles (MNPs) with good magnetic properties, biocompatibility, and anticancer activities by photodynamic therapy (PDT), we synthesized multifunctional cobalt ferrite (CoFe2O4) nanoparticles (CoFe2O4-HPs-FAs) functionalized by coating them with hematoporphyrin (HP) for introducing photo-functionality and by conjugating with folic acid (FA) for targeting cancer cells. We evaluated the activities of the CoFe2O4-HPs-FAs by checking magnetic resonance imaging (MRI) in vitro, its biocompatibility, and photodynamic anticancer activities on FA receptor (FR)-positive and FR-negative cancer cell lines, Hela, KB, MCF-7, and PC-3 cells, to use for clinical applications. In this study, we have demonstrated that the CoFe2O4-HPs-FAs have good MRI and biocompatibility with non-cytotoxicity, and remarkable photodynamic anticancer activities at very low concentrations regardless of cell types. Particularly, the photo-killing abilities in 3.13 μg/mL of CoFe2O4-HPs-FAs were measured to be 91.8% (p < 0.002) for Hela, 94.5% (p < 0.007) for KB, 79.1% (p < 0.003) for MCF-7, and 71.3% (p < 0.006) for PC-3. The photodynamic anticancer activities in 6.25 and 12.5 μg/mL of CoFe2O4-HPs-FAs were measured to b...Continue Reading

Citations

Apr 26, 2016·BioMed Research International·Kyong-Hoon ChoiBong Joo Park
May 28, 2016·Journal of Nanobiotechnology·Ewelina PiktelRobert Bucki
Sep 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyong-Hoon ChoiBong Joo Park
Jun 13, 2017·Nanomaterials·Kyong-Hoon ChoiBong Joo Park
Nov 14, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Siddhi ChaudhuriSamir Kumar Pal
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Duy Khuong MaiHo-Joong Kim
Jun 15, 2021·Photochemistry and Photobiology·Chloe B SmithAlvin A Holder

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