PMID: 20644595Jul 21, 2010Paper

Photodynamic antimicrobial chemotherapy by liposome-encapsulated water-soluble photosensitizers

Bioorganicheskaia khimiia
Marina NisnevitchYeshayahu Nitzan

Abstract

Photodynamic antimicrobial chemotherapy is an alternative method for killing bacterial cells in view of the increasing problem of multi-antibiotic resistance. We examined the effect of three water-soluble photosensitizers (PhS): methylene blue (MB), neutral red (NR) and rose bengal (RB) on Gram-positive and Gram-negative bacteria. We compared the efficacy of PhS in their free form and encapsulated in liposomal formulations against various bacterial strains, and determined conditions for the effective use of encapsulated PhS. We found that all three PhS were able to eradicate the Gram-positive microbes Staphylococcus aureus and Sarcina lutea; and MB and RB were effective against St. epidermidis. In the case of the Gram-negative species, MB and RB were cytotoxic against the Shigella flexneri, NR-inactivated Escherichia coli and Salmonella para B, and BR was effective in killing Pseudomonas aeruginosa. None of the examined PhS showed activity against Klebsiella pneumoniae. MB and NR enclosed in liposomes gave a stronger antimicrobial effect than free PhS for all tested prokaryotes, whereas encapsulation of RB led to no increase in its activity. We suggest that encapsulation of PhS can increase the photoinactivation of bacteria.

References

Aug 1, 1977·Mutation Research·B GutterH S Rosenkranz
Jul 15, 1992·Journal of Photochemistry and Photobiology. B, Biology·Z MalikY Nitzan
May 22, 1998·Journal of Photochemistry and Photobiology. B, Biology·Y NitzanH Ashkenazi
Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·M Wainwright
Dec 30, 1998·Journal of Photochemistry and Photobiology. B, Biology·G H RodalK Berg
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·P M FurneriG Tempera
Mar 17, 2001·The Journal of Antimicrobial Chemotherapy·S M McAllisterM R Brown
Jun 19, 2002·Current Pharmaceutical Design·Kunikazu Moribe, Kazuo Maruyama
Feb 19, 2003·FEMS Immunology and Medical Microbiology·Helena AshkenaziYeshayahu Nitzan
Jan 7, 2004·Advanced Drug Delivery Reviews·Annelies S L Derycke, Peter A M de Witte
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yeshayahu NitzanZvi Malik
May 25, 2004·Antimicrobial Agents and Chemotherapy·Faten GadMichael R Hamblin
Jan 29, 2005·Journal of Liposome Research·Hee-Jeong Kim, Malcolm N Jones
Feb 8, 2005·Biophysical Journal·Giuseppe MaulucciGiuseppe Briganti
May 27, 2005·Antimicrobial Agents and Chemotherapy·Tatiana N Demidova, Michael R Hamblin
Nov 22, 2005·Expert Opinion on Drug Delivery·Bin ChenTayyaba Hasan
Nov 24, 2005·Cancer Letters·Yasuyuki SadzukaTakashi Sonobe
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·George P Tegos, Michael R Hamblin
Jan 27, 2006·Photochemistry and Photobiology·Shimshon Ben-DrorBenjamin Ehrenberg
Feb 1, 2006·Journal of Photochemistry and Photobiology. B, Biology·Stefania FerroGiulio Jori
Feb 14, 2006·International Journal of Antimicrobial Agents·Gavin RukholmAbdelwahab Omri
May 26, 2006·Antimicrobial Agents and Chemotherapy·Clement MugabeAbdelwahab Omri
Mar 28, 2007·The International Journal of Biochemistry & Cell Biology·Stefania FerroGiulio Jori

❮ Previous
Next ❯

Citations

Aug 10, 2012·Cell Biochemistry and Biophysics·Marina NisnevitchYeshayahu Nitzan
Oct 1, 2010·Photochemistry and Photobiology·Faina NakonechnyMarina Nisnevitch
Mar 20, 2013·BioMed Research International·Faina NakonechnyMarina Nisnevitch
Aug 27, 2014·International Journal of Molecular Sciences·Anton ValkovMarina Nisnevitch
Nov 11, 2011·Journal of Photochemistry and Photobiology. B, Biology·Juliana P M L RolimLidiany K A Rodrigues
Mar 18, 2011·Lasers in Surgery and Medicine·Stefan KranzBernd W Sigusch
Nov 21, 2012·Photochemistry and Photobiology·Faina NakonechnyMarina Nisnevitch
Nov 8, 2011·Lasers in Surgery and Medicine·Cheng S Jin, Gang Zheng
Jul 3, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mohan VimaladeviAgnishwar Girigoswami
Jun 12, 2019·Laser Therapy·Jaber GhorbaniAbbas Bahador
Dec 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yana IlizirovMarina Nisnevitch
Jul 3, 2019·International Journal of Molecular Sciences·Faina NakonechnyMarina Nisnevitch
Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariana Q MesquitaM Amparo F Faustino
Mar 7, 2021·Pathogens·Anton ValkovMarina Nisnevitch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.