Photodynamic antimicrobial effects of bis-indole alkaloid indigo from Indigofera truxillensis Kunth (Leguminosae)

Lasers in Medical Science
Nathalia L AndreazzaMarcos Jose Salvador

Abstract

Multidrug-resistant microbial infections represent an exponentially growing problem affecting communities worldwide. Photodynamic therapy is a promising treatment based on the combination of light, oxygen, and a photosensitizer that leads to reactive oxygen species production, such as superoxide (type I mechanism) and singlet oxygen (type II mechanism) that cause massive oxidative damage and consequently the host cell death. Indigofera genus has gained considerable interest due its mutagenic, cytotoxic, and genotoxic activity. Therefore, this study was undertaken to investigate the effect of crude extracts, alkaloidal fraction, and isolated substance derived from Indigofera truxillensis in photodynamic antimicrobial chemotherapy on the viability of bacteria and yeast and evaluation of mechanisms involved. Our results showed that all samples resulted in microbial photoactivation in subinhibitory concentration, with indigo alkaloid presenting a predominant photodynamic action through type I mechanism. The use of CaCl2 and MgCl2 as cell permeabilizing additives also increased gram-negative bacteria susceptibility to indigo.

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Citations

Nov 15, 2019·Medical Mycology·Lucía GiaconeMaximiliano Sortino
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqin XuXinjun Xu
Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki
May 6, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Agustín A GodoyGriselda E Narda
Jun 3, 2021·Biomedicines·Ece Polat, Kyungsu Kang

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