PMID: 9423904Jan 10, 1998Paper

Photodynamic biologic tissue glue to enhance corneal wound healing after radial keratotomy

Journal of Cataract and Refractive Surgery
K M GoinsJ T Ernest

Abstract

To evaluate the effect of photodynamic biologic tissue glue (PBTG) on corneal wound healing after radial keratotomy (RK). Cornea Research Laboratory, The University of Chicago, Chicago, Illinois, USA. Bidirectional, eight-incision RK was done in one eye of eight Dutch pigmented rabbits. Then, PBTG was inserted into the RK incisions and activated with an argon blue-green laser in four treatment eyes. The rabbits were divided into three groups: early, in which corneal wound healing was assessed at 1 and 3 weeks; late, in which corneal wound healing was assessed at 8 weeks; enhancement. The PBTG-treated keratotomy wounds had a more prominent epithelial healing response immediately after RK and a decreased propensity for wound dehiscence. Collagen fiber arrangement in the PBTG-treated incisions was sagittal to the keratotomy wound 1 to 3 weeks after RK and then changed to a transverse orientation across the keratotomy wound by 8 weeks. The control keratotomy wounds had a less prominent epithelial healing response and developed late disorganization of the posterior keratotomy wound at 8 weeks. Keratometry measurements 2 months after RK showed corneal flattening of 1.0 diopter (D) in the PBTG-treated eye and 6.5 D in the control eye,...Continue Reading

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Citations

Oct 25, 2003·Cornea·Hosam A Ibrahim-ElzembelyHerbert E Kaufman
Jun 22, 2005·Cornea·Roswell R Pfister, Charnell Inglis Sommers
Aug 11, 2012·Investigative Ophthalmology & Visual Science·Stacy L LittlechildGary W Conrad
Nov 3, 2004·Journal of Cataract and Refractive Surgery·Cinthia E ProanoIrene E Kochevar
Nov 12, 2003·Experimental Eye Research·Adrienne CsutakAndrás Berta
Oct 20, 2004·Lasers in Surgery and Medicine·John KhademMichael R Hamblin
Dec 16, 1998·Journal of Cataract and Refractive Surgery·K M GoinsP A Majmudar

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