PMID: 11323397Apr 27, 2001Paper

Photodynamic DNA damage mediated by delta-aminolevulinic acid-induced porphyrins

Carcinogenesis
P DuezJ Dubois

Abstract

The mutagenic properties of UVA are thought to be predominantly radical-mediated, which supposes endogenous sensitizers. In order to investigate a possible role of porphyrins, their synthesis was induced in a murine leukemia P388D1 cell model by treatment with delta-aminolevulinic acid (delta-ala). Intra-cellular protoporphyrin IX reached a plateau after about 2 h, whereas soluble porphyrins, probably the photostable uro- and/or coproporphyrins, were excreted. Irradiation of treated cells by UVA (tanning lamp) but also by visible light was found to generate in DNA a significant increase of 8-oxo-7,8-dihydro-2'-deoxyguanosine, a mutagenic marker of oxidative damage. The different parameters involved in this photodynamic effect are reported, namely delta-ala concentration and loading time, light dosage and the influence of intracellular and medium-excreted porphyrins. These results point to an implication of porphyrins in solar-induced carcinogenicity but also in possible adverse effects of the medical applications of photodynamic therapy and diagnosis.

Citations

Apr 15, 2004·The Science of the Total Environment·V MuzykaT Veidebaum
Mar 29, 2003·Journal of Hepatology·Thomas S WeissWolfgang E Thasler
Jul 8, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jean CadetPaolo Di Mascio
Jan 5, 2008·Photochemistry and Photobiology·Gary M Halliday, Sabita Rana
Aug 19, 2015·Journal of Ethnopharmacology·Amandine NachtergaelPierre Duez
Jan 29, 2008·Journal of Photochemistry and Photobiology. B, Biology·Kristóf ZupánGabriella Csík
May 17, 2006·The Journal of Dermatology·Ikbal Esen AydingözZuhal Erçin
Jul 1, 2006·Photochemistry and Photobiology·Jean CadetPaolo Di Mascio
Aug 22, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Etelvino J H BecharaNilson A Assunção
Oct 21, 2014·Photochemistry and Photobiology·Jean CadetJean-Luc Ravanat
Nov 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Leandro M O LourençoJoão P C Tomé
Feb 16, 2021·Nucleosides, Nucleotides & Nucleic Acids·Surajit HansdaRita Ghosh
Dec 7, 2006·Journal of Cell Science·Anna CampalansJ Pablo Radicella
Feb 6, 2019·Chemical Reviews·Paolo Di MascioJean Cadet

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