Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck

Lasers in Surgery and Medicine
B M LippertJ A Werner

Abstract

In the last years, photodynamic therapy, performed with hematoporphyrin derivatives, gained in importance for the treatment of superficially situated malignomas. The use of hematoporphyrin as photosensitizer is limited especially by the low depth of penetration and its side effects. The aim of the present study was to evaluate the effectiveness of photodynamic therapy with anthracyclin derivates in squamous cell carcinoma cell lines. The photodynamic effects of the anthracyclin derivates adriamycin and epirubicin as well as the effects of the hematoporphyrin derivatives photofrin-II and photosan-3 were examined and compared in 10 squamous cell carcinoma cell lines derived from head and neck tumors. Beside their cytostatic effect, the applied cytostatics revealed a marked photodynamic effect. A statistically significant difference for photodynamic effects of both cytostatic agents and the hematoporphyrin derivates could not be shown. These results revealed that the above mentioned cytostatics could be considered as possible alternative photosensitizer for photodynamic therapy.

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Citations

Dec 17, 2005·Photomedicine and Laser Surgery·Marcos B PaivaJoel Sercarz
Apr 20, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H J RenL Ming
Sep 21, 2013·Translational Vision Science & Technology·Alex L C TamYeni H Yücel

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