Abstract
We have investigated the photodynamic activity of a new chlorin-type photosensitizer on a reference human immunodeficiency virus type 1 (HIV-1) strain, two wild-type HIV-1 isolates and two drug-resistant HIV-1 isolates. This chlorin was highly effective for the inactivation of free viruses, as assessed by two different quantitative cell culture assays. In the absence of blood components, all the HIV strains, including wild-type and drug-resistant mutant isolates, were totally inactivated using 30 micrograms ml-1 of chlorin and 0.75 J cm-2 of 661 nm light. Successful killing of HIV-1 strains in either plasma or whole blood was also obtained by increasing the chlorin concentration moderately. Our results demonstrate the antiviral efficiency of this chlorin, suggesting the potential application of dye-sensitized photoirradiation to decontaminate blood products.
References
Apr 1, 1977·Photochemistry and Photobiology·F Rapp, B A Kemeny
Aug 16, 1992·The New England Journal of Medicine·J G DonahueK E Nelson
May 1, 1992·Journal of Virological Methods·F Brun-VézinetC Buffet-Janvresse
Jun 1, 1991·Transfusion·K N ProdouzJ C Fratantoni
Feb 1, 1991·Antiviral Research·J B HudsonG H Towers
Dec 30, 1991·Annals of the New York Academy of Sciences·E BisacciaA Klainer
Apr 1, 1991·Photochemistry and Photobiology·J Moan, K Berg
Feb 1, 1991·Transfusion·B HorowitzJ Valinsky
Jan 1, 1991·Photochemistry and Photobiology·M M JudyS T Nichol
Jul 1, 1991·Transfusion·R Y DoddL E Benade
Dec 1, 1988·AIDS Research and Human Retroviruses·O SchwartzL Montagnier
Oct 5, 1989·The New England Journal of Medicine·P D CummingR Y Dodd
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R C AloiaL M Gordon
Jan 1, 1988·Transfusion·J L MatthewsT C Chanh
Nov 1, 1987·Photochemistry and Photobiology·F SieberL L Sensenbrenner
Jul 1, 1987·Photochemistry and Photobiology·G H Towers, J B Hudson
Jan 12, 1995·Nature·X WeiB H Hahn
May 1, 1995·Transfusion·G N Vyas
Jan 12, 1995·Nature·D D HoM Markowitz
Jun 4, 1994·Lancet·I Loussert-AjakaF Simon
Aug 1, 1994·Photochemistry and Photobiology·S RywkinB Horowitz
Aug 16, 1994·Biochemistry·K Kuzelová, D Brault
Apr 15, 1994·Journal of Medicinal Chemistry·A K DebnathA R Neurath
May 1, 1993·Photochemistry and Photobiology·S J WagnerR Y Dodd
Mar 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·S Legrand-PoelsJ Piette
Citations
Dec 3, 2003·Biochimica Et Biophysica Acta·M EgyekiG Csík
Dec 13, 2003·Antiviral Research·Julien DairouDaniel Brault
Oct 21, 2009·Marine Drugs·Adelaide AlmeidaMaria A F Faustino
Feb 15, 2001·Expert Opinion on Investigational Drugs·I StojiljkovicV Kumar
May 3, 2001·Photochemistry and Photobiology·D BraultM T Martin
Jan 6, 2000·FEBS Letters·C Vever-BizetC Hélène
Jan 19, 2007·The Journal of Physical Chemistry. B·Clare BradyColin P McCoy
Nov 25, 2003·Journal of Chemical Information and Computer Sciences·Rozália VanyúrJudit Jakus