Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles

ACS Omega
Niranga WijesiriPeng Zhang

Abstract

Multidrug-resistant Staphylococcus aureus (MRSA) has become one of the major causes of various infections, leading to morbidity in both healthy and immune-compromised populations worldwide. Herein, we report a novel type of hybrid photosensitizer based on amphiphilic block copolymer-functionalized gold nanoparticles. The design of the nanoparticles provides a facile means to incorporate hydrophobic photosensitizing molecules for use in aqueous media. The hybrid photosensitizers display greatly enhanced singlet oxygen generation and outstanding photodynamic inactivation (PDI) efficacy against MRSA under light illumination. These hybrid photosensitizers greatly improve the effectiveness of PDI against MRSA while not involving antibiotics.

References

Jun 4, 1974·Biochemical and Biophysical Research Communications·J S BusJ E Gibson
Aug 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·F Ricchelli
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E CosgroveYehuda Carmeli
Mar 26, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Teruyo ItoKeiichi Hiramatsu
May 2, 2003·Nature Reviews. Cancer·Dean W Felsher
May 15, 2003·Chemical Reviews·Claude Schweitzer, Reinhard Schmidt
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Giulio Jori, Stanley B Brown
Sep 15, 2004·Biochimica Et Biophysica Acta·Ramiro D AlmeidaCarlos B Duarte
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kepler A DavisDuane R Hospenthal
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stan Deresinski
Apr 9, 2005·The New England Journal of Medicine·Loren G MillerBrad Spellberg
Aug 11, 2006·The Journal of Physical Chemistry. B·J KimlingA Plech
Mar 27, 2007·Cell·Michael N Alekshun, Stuart B Levy
Jan 29, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Loren G Miller, Binh An Diep
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George Sakoulas, Robert C Moellering
Jul 1, 2008·Trends in Microbiology·Binh An Diep, Michael Otto
May 2, 2009·Journal of Photochemistry and Photobiology. B, Biology·C A RobertsonH Abrahamse
Mar 9, 2010·Lancet·Frank R DeLeoHenry F Chambers
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·Ana P CastanoMichael R Hamblin

❮ Previous
Next ❯

Citations

May 18, 2021·International Journal of Biological Macromolecules·Lin YueZhouping Wang
Dec 12, 2018·Journal of the American Chemical Society·Nicolas MaciaBelinda Heyne

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
Fluorescence
phosphorescence
Assay

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.