Abstract
Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective photosensitiser dyes, tissue oxygen and targeted illumination to generate cytotoxic reactive oxygen species (ROS) within the tumour. In addition to directly acting on tumour cells, PDT damages and restricts tumour microvasculature, and causes a local inflammatory response that stimulates an immune response against the tumour. Unlike surgery or radiotherapy, the surrounding extracellular matrix is unaffected by PDT; thus, tissue healing is excellent and PDT seldom causes scars. This, combined with the ease of light application, has made PDT a popular treatment for cancers and pre-cancerous conditions in human beings. Moreover, because photosensitiser dyes are fluorescent and selectively accumulate in tumour tissues, they can additionally be used to visualise and discriminate tumour from normal tissues, thereby improving the accuracy of tumour surgery. In veterinary practice, PDT has been used successfully for treatment of superficial squamous cell carcinomas of the feline nasal planum; urinary tract, urinary bladder and prostate neoplasia in dogs; and equine sarc...Continue Reading
Citations
Jun 2, 2018·Cancer Medicine·Ziyu YeJincheng Zeng
Aug 14, 2018·Current Opinion in Urology·Akbar N AshrafiInderbir S Gill
May 3, 2019·The Analyst·Benjamin GardnerNick Stone
Apr 25, 2020·Journal of Clinical Medicine·Martha BaydounNadira Delhem
May 30, 2020·International Journal of Molecular Sciences·Anine Crous, Heidi Abrahamse
Jul 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingyao SunZhaogang Yang
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadine S JamesRavindra K Pandey
Mar 3, 2019·Lasers in Medical Science·Yixin ZhengQingyong Li
Sep 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Channay NaidooHeidi Abrahamse
Jan 3, 2021·Photochemistry and Photobiology·Anastasios PanagopoulosKonstantina C Fylaktakidou
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salvador GomezZhiwei Hu
Nov 3, 2020·Frontiers in Chemistry·Houhe LiuChuanshan Xu
Mar 7, 2021·Pharmaceutics·Hanieh MontaseriHeidi Abrahamse
Apr 30, 2021·Expert Opinion on Therapeutic Patents·José Marcos Teixeira de Alencar FilhoLarissa Araújo Rolim
Jun 18, 2021·Nano-micro Letters·Qinjun ChenChen Jiang
Jun 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zewei WeiXiao Zhu
Aug 20, 2021·Frontiers in Chemistry·Gurcan GunaydinSeylan Ayan
May 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zeting YuanKe Xu
Oct 23, 2018··Cancan HuHong Cai